Document Detail

Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates.
MedLine Citation:
PMID:  11849577     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity. METHODS: We evaluated 10 infants born by vaginal delivery (group A), 10 infants born by caesarean section after epidural anaesthesia with lidocaine (group B) and 10 infants born by caesarean section after general anaesthesia with sevoflurane (group C). RESULTS: A significant reduction of neutrophil respiratory burst test was found in groups A and C compared with group B. Natural killer cell (NK) activity with an effector : target ratio of 30 : 1 (NK30) and 10 : 1 (NK10) was significantly higher in group A compared with the B and C groups. In addition, thyroid stimulating hormone (TSH) concentration was significantly reduced in group A compared with the B and C groups. A significant negative correlation was found between TSH and NK30 or NK10. CONCLUSIONS: Our results suggest that the mode of delivery and anaesthesia can significantly modify the endocrine-immune system in the newborn. Caesarean section delivery with regional anaesthesia seems to produce fewer modifications of neonatal immune function compared with general anaesthesia.
A Gasparoni; L Ciardelli; D De Amici; A M Castellazzi; M Autelli; R Bottino; E Polito; A Bartoli; G Rondini; G Chirico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  12     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Research Laboratories, Policlinico San Matteo, IRCCS, Pavia, Italy.
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MeSH Terms
Anesthesia, Epidural*
Anesthesia, General*
Anesthesia, Obstetrical*
Anesthetics, Inhalation
Anesthetics, Local
Cesarean Section
Delivery, Obstetric
Infant, Newborn / immunology*,  metabolism*
Killer Cells, Natural / immunology*
Methyl Ethers
Neutrophils / immunology
Respiratory Burst
Thyroid Hormones / metabolism*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Local; 0/Methyl Ethers; 0/Thyroid Hormones; 137-58-6/Lidocaine; 28523-86-6/sevoflurane

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