| Effect of general anesthetics and pressure on aerobic metabolism of monkey kidney cells. | |
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MedLine Citation:
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PMID: 6742483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors examined the inhibition of aerobic metabolism in monkey kidney cell cultures exposed to halothane, enflurane, and isoflurane. The ability of hyperbaric pressure to reverse the halothane-induced metabolic inhibition also was examined. Incubation of two monkey kidney cell lines for 24 h with clinically equipotent concentrations (2.6 MAC) of halothane, enflurane, or isoflurane vapors increased the concentration of lactate in the media by 126 to 244% relative to nonexposed control cultures. The increased rate of lactate accumulation was proportional to the concentration of halothane and was accompanied by a decrease in media pH. Removal of halothane restored the normal rate of lactate production. Hyperbaric pressures of 25, 50, and 100 atmospheres did not alter the halothane-stimulated rate of lactate production relative to non-anesthetic-treated controls, although pressure alone did depress the rate of lactate accumulation in all cultures. The stimulation of lactate production likely reflects the known ability of halothane to inhibit mitochondrial respiration. The failure of pressure to reverse the stimulation of lactate production by halothane suggests that inhibition of mitochondrial metabolism cannot be reversed by pressure. |
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Authors:
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M J Brabec; E Bedows; B A Davidson; P R Knight |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anesthesiology Volume: 61 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-07-31 Completed Date: 1984-07-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 43-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerobiosis Anesthesia, General* Animals Cell Line Cells, Cultured Cercopithecus aethiops Enflurane / pharmacology Halothane / pharmacology Isoflurane / pharmacology Kidney / drug effects, metabolism* Kinetics Lactates / metabolism Pressure |
| Grant Support | |
ID/Acronym/Agency:
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GM00477-03/GM/NIGMS NIH HHS; R01 GM28911/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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