Document Detail

Effect of gastric bypass on gastric secretion.
MedLine Citation:
PMID:  1251957     Owner:  NLM     Status:  MEDLINE    
Gastric bypass as a 90 per cent gastric exclusion operation was used in 393 patients with massive obesity to limit food intake. Stomal ulcer has occurred in 1.8 per cent of such patients or one ulcer per 140 man years of observation. The studies of indwelling fundic pH and of gastric acid secretion from the excluded stomach indicate that acid secretion is reduced after gastric bypass but that the acid, unbuffered by food in the excluded stomach, results in a lowered gastrin secretion after a meal. Thus, gastric bypass in inhibitory to acid secretion in most morbidly obese patients who do not have known acid peptic disease.
E E Mason; J R Munns; G P Kealey; R Wangler; W R Clarke; H F Cheng; K J Printen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of surgery     Volume:  131     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-10     Completed Date:  1976-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  AIM; IM    
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MeSH Terms
Achlorhydria / chemically induced
Analysis of Variance
Gastric Acidity Determination
Gastric Juice / drug effects,  secretion*
Gastric Mucosa / drug effects,  secretion
Gastrins / blood
Gastroenterostomy* / adverse effects
Obesity / surgery*
Peptic Ulcer / surgery
Stomach Ulcer / etiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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