Document Detail


Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  15522140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have cast doubt on the proposed lipid-lowering and blood pressure-lowering effects of garlic. We tested the effect of dried garlic (Allium sativum) powder on blood lipids, blood pressure and arterial stiffness in a 12-week randomised, double-blind, placebo-controlled trial. Seventy-five healthy, normo-lipidaemic volunteers (men and women aged 40-60 years) were assigned to dried garlic powder tablets (10.8 mg alliin (3-(2-propenylsulfinyl)-L-alanine)/d, corresponding to about three garlic cloves) or placebo. Sixty-two subjects were eligible for the per-protocol analysis. The primary outcome measure was serum total cholesterol concentration. Secondary outcome measures were LDL-cholesterol, HDL-cholesterol and triacylglycerol concentrations, blood pressure and arterial stiffness (assessed by pulse wave velocity). No significant differences between the garlic and placebo groups were detected for any of the outcome measures. However, garlic powder was associated with a near-significant decrease (12 %) in triacylglycerol concentration (P=0.07). In conclusion, garlic powder tablets have no clinically relevant lipid-lowering and blood pressure-lowering effects in middle-aged, normo-lipidaemic individuals. The putative anti-atherosclerotic effect of garlic may be linked to risk markers other than blood lipids.
Authors:
Beate Turner; Christian Mølgaard; Peter Marckmann
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of nutrition     Volume:  92     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2004-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  701-6     Citation Subset:  IM    
Affiliation:
Dansk Droge, Ishøj, Denmark. belotu@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / drug effects
Blood Pressure / drug effects*
Cholesterol / blood
Double-Blind Method
Female
Garlic*
Humans
Lipids / blood*
Male
Middle Aged
Phytotherapy*
Plant Extracts / pharmacology*
Pulsatile Flow / drug effects
Triglycerides / blood
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Lipids; 0/Plant Extracts; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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