| Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 15522140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have cast doubt on the proposed lipid-lowering and blood pressure-lowering effects of garlic. We tested the effect of dried garlic (Allium sativum) powder on blood lipids, blood pressure and arterial stiffness in a 12-week randomised, double-blind, placebo-controlled trial. Seventy-five healthy, normo-lipidaemic volunteers (men and women aged 40-60 years) were assigned to dried garlic powder tablets (10.8 mg alliin (3-(2-propenylsulfinyl)-L-alanine)/d, corresponding to about three garlic cloves) or placebo. Sixty-two subjects were eligible for the per-protocol analysis. The primary outcome measure was serum total cholesterol concentration. Secondary outcome measures were LDL-cholesterol, HDL-cholesterol and triacylglycerol concentrations, blood pressure and arterial stiffness (assessed by pulse wave velocity). No significant differences between the garlic and placebo groups were detected for any of the outcome measures. However, garlic powder was associated with a near-significant decrease (12 %) in triacylglycerol concentration (P=0.07). In conclusion, garlic powder tablets have no clinically relevant lipid-lowering and blood pressure-lowering effects in middle-aged, normo-lipidaemic individuals. The putative anti-atherosclerotic effect of garlic may be linked to risk markers other than blood lipids. |
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Authors:
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Beate Turner; Christian Mølgaard; Peter Marckmann |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The British journal of nutrition Volume: 92 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-03 Completed Date: 2004-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 701-6 Citation Subset: IM |
Affiliation:
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Dansk Droge, Ishøj, Denmark. belotu@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / drug effects Blood Pressure / drug effects* Cholesterol / blood Double-Blind Method Female Garlic* Humans Lipids / blood* Male Middle Aged Phytotherapy* Plant Extracts / pharmacology* Pulsatile Flow / drug effects Triglycerides / blood Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Plant Extracts; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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