| Effect of gamma irradiation on the efficacy of beta-glucan against acetaminophen induced toxicity in mice. | |
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MedLine Citation:
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PMID: 19109935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was conducted to compare the efficacy of unirradiated beta-glucan (UBG) and gamma irradiated beta-glucan (GIBG) against acetaminophen (APAP) induced hepatotoxicity in mice. Mice of BALB/c strain were pretreated with UBG and GIBG (50mg/kg, p.o.) for 7 days and on the 8th day they received an overdose of APAP (500 mg/kg, i.p.). Eight hours after the APAP injection, the levels of serum aminotransferase (AST) and alanine aminotransferase (ALT) were measured and liver, kidney and lung tissue were examined for morphological changes. A significant elevation (p<0.001) of the levels of AST and ALT was observed in mice toxicated with APAP. Histology data revealed severe liver centrilobular necrosis, portal vein damage with apparent toxicity in renal glomerulus and lung inflammation associated with edema. However, a significant inhibition (p<0.05) in the elevation of AST and ALT was observed in mice that received UBG and GIBG compared with APAP-treated mice. Histology examination revealed the non-statistical difference between the protective effects of GIBG and UBG against acetaminophen challenge. In conclusion, it was demonstrated that gamma irradiation induced no severe alteration in the protective activity of beta-glucan against APAP-induced hepatotoxicity. |
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Authors:
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Ju-Woon Lee; Eui-Hong Byun; Nak-Yun Sung; Hanumantha Rao Balaji Raghavendran; Eui-Baek Byun; Jae-Hun Kim; Jong-Il Choi; Myung-Gon Shin; Myung-Woo Byun |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-06 |
Journal Detail:
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Title: Chemico-biological interactions Volume: 180 ISSN: 1872-7786 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: Ireland |
Other Details:
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Languages: eng Pagination: 98-105 Citation Subset: IM |
Affiliation:
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Team for Radiation Food Science & Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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toxicity* Analgesics, Non-Narcotic / toxicity* Animals Gamma Rays* Kidney / cytology, drug effects Liver / cytology, drug effects*, enzymology Lung / cytology, drug effects Mice Mice, Inbred BALB C beta-Glucans / pharmacology*, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 0/beta-Glucans; 103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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