Document Detail

Effect of gamma, ethylene oxide, electron beam, and plasma sterilization on the behaviour of SR-PLLA fibres in vitro.
MedLine Citation:
PMID:  12555899     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the effect of various sterilization processes on the physical and mechanical properties of self-reinforced bioabsorbable fibres made out of polylactide (PLLA). The samples were sterilized using plasma, ethylene oxide (one and two cycles), gamma (25 kGy at room temperature, 25 kGy in dry ice, and 2 x 25 kGy at room temperature), and electron beam (15, 25, and 55 kGy) sterilization. The intrinsic viscosity, crystallinity, and mechanical properties (modulus of elasticity, yield strength, and ultimate tensile strength) were tested before and immediately after each sterilization treatment, as well as up to 30 weeks in vitro. Compared with unsterilized fibres, the intrinsic viscosity was markedly decreased after radiation sterilization (gamma and electron beam) and the loss in mechanical properties was accelerated during in vitro degradation. Plasma and ethylene oxide (one and two cycles) did not markedly alter the properties of the samples after sterilization or during in vitro degradation. These data are important for determining the effect of various sterilization processes on the physical and mechanical properties of polylactide-based materials and can be used to predict how fast degradation of the mechanical properties of the self-reinforced PLLA will occur. They can also be used to tailor the degradation kinetics to optimize implant design.
Juha-Pekka Nuutinen; Claude Clerc; Tuija Virta; Pertti Törmälä
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomaterials science. Polymer edition     Volume:  13     ISSN:  0920-5063     ISO Abbreviation:  J Biomater Sci Polym Ed     Publication Date:  2002  
Date Detail:
Created Date:  2003-01-30     Completed Date:  2003-07-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9007393     Medline TA:  J Biomater Sci Polym Ed     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1325-36     Citation Subset:  IM    
Institute of Biomaterials, Tampere University of Technology, PO Box 589, FIN-33101, Tampere, Finland.
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MeSH Terms
Absorbable Implants*
Beta Particles
Biocompatible Materials*
Calorimetry, Differential Scanning
Ethylene Oxide*
Gamma Rays*
Materials Testing / methods
Polyesters / chemistry*
Sterilization / methods*
Tensile Strength
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyesters; 26969-66-4/poly(lactide); 75-21-8/Ethylene Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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