Document Detail

Effect of gamma-aminobutyric acid-enriched tempeh-like fermented soybean (GABA-Tempeh) on the blood pressure of spontaneously hypertensive rats.
MedLine Citation:
PMID:  12951518     Owner:  NLM     Status:  MEDLINE    
GABA-enriched tempeh-like fermented soybean (GABA-tempeh) was supplemented to the AIN-76 diet and fed for 2 months to spontaneously hypertensive rats (SHRs), an animal model of spontaneously developed hypertension, to compare the antihypertensive activity with that of authentic GABA. The elevation of systolic blood pressure in SHRs was significantly retarded in the GABA-tempeh group as well as that with authentic GABA when compared with the controls, and the effect lasted for two months of the feeding period. The blood urea nitrogen level tended to be higher in the control group than in the GABA-supplemented groups. On the other hand, no effect was apparent on the plasma levels of cholesterol, triacylglycerol and glucose, or on the urinary excretion of Na and K.
Hideyuki Aoki; Yuji Furuya; Yasushi Endo; Kenshiro Fujimoto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  67     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-02     Completed Date:  2004-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1806-8     Citation Subset:  IM    
Research Laboratory, Ikeda Tohka Industries Co., Ltd., 95-7 Minooki-cho, Fukuyama, Hiroshima 721-0956, Japan.
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MeSH Terms
Animal Feed
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects*
Food, Fortified
Rats, Inbred SHR
Soy Foods*
Soybeans / chemistry*,  metabolism
Time Factors
gamma-Aminobutyric Acid / pharmacology*
Reg. No./Substance:
0/Antihypertensive Agents; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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