Document Detail

Effect of gamma 2-melanocyte-stimulating hormone on cerebral blood flow in rats.
MedLine Citation:
PMID:  7564334     Owner:  NLM     Status:  MEDLINE    
The effects of the proopiomelanocortin-(POMC)-derived peptide gamma 2-melanocyte-stimulating hormone (gamma 2-MSH) on mean arterial blood pressure (BP: MAP), heart rate (HR), internal and total carotid blood flow (BF) (CFint and CFtot, respectively), and regional cerebrocortical blood flow (CBF) were measured in urethane-anesthetized rats after intravenous (i.v.) and intracarotid ( administration of the peptide. gamma 2-MSH (1.5-100 nmol/kg) administered i.v. and caused a dose-dependent increase in MAP and HR. Injection of the peptide in the middose range resulted in a more pronounced pressor effect. Furthermore, the earlier onset of the hemodynamic effects after injection suggests that forebrain structures play a role in these effects. In addition to the pressor response, gamma 2-MSH produced a strong increase in CFint, CFtot, and CBF after both routes of administration, suggesting an increased intracerebral BF. Whereas the effects of the higher doses of gamma 2-MSH on MAP and CFtot were quantitatively comparable after either the intravenous or intracarotid administration, the effect on regional CBF and CFint was about twice as high after infusion, indicating a centrally mediated phenomenon underlying this effect on CBF. The increase in CFint cannot in itself be ascribed to a gamma 2-MSH-mediated higher perfusion pressure (i.e., BP), since an equipressor dose of norepinephrine (NE) caused a significant decrease in CFint. The significant and more than twofold higher increase in CBF after intracarotid administration of gamma 2-MSH in comparison with administration of NE by the same route also suggests a central origin for the enhancement of microcirculatory flow due to the peptide.
D J de Wildt; C M Kasbergen; D H Versteeg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  25     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-905     Citation Subset:  IM    
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Medical Faculty, Utrecht University, The Netherlands.
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MeSH Terms
Blood Gas Analysis
Blood Pressure / drug effects*
Carotid Arteries / drug effects,  physiology
Cerebrovascular Circulation / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects*
Injections, Intra-Arterial
Injections, Intravenous
Laser-Doppler Flowmetry
Melanocyte-Stimulating Hormones / administration & dosage,  pharmacology*
Norepinephrine / pharmacology
Rats, Wistar
Regional Blood Flow / drug effects
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 9002-79-3/Melanocyte-Stimulating Hormones

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