Document Detail


Effect of gamma 2-melanocyte-stimulating hormone on cerebral blood flow in rats.
MedLine Citation:
PMID:  7564334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the proopiomelanocortin-(POMC)-derived peptide gamma 2-melanocyte-stimulating hormone (gamma 2-MSH) on mean arterial blood pressure (BP: MAP), heart rate (HR), internal and total carotid blood flow (BF) (CFint and CFtot, respectively), and regional cerebrocortical blood flow (CBF) were measured in urethane-anesthetized rats after intravenous (i.v.) and intracarotid (i.car.) administration of the peptide. gamma 2-MSH (1.5-100 nmol/kg) administered i.v. and i.car. caused a dose-dependent increase in MAP and HR. Injection of the peptide i.car. in the middose range resulted in a more pronounced pressor effect. Furthermore, the earlier onset of the hemodynamic effects after i.car. injection suggests that forebrain structures play a role in these effects. In addition to the pressor response, gamma 2-MSH produced a strong increase in CFint, CFtot, and CBF after both routes of administration, suggesting an increased intracerebral BF. Whereas the effects of the higher doses of gamma 2-MSH on MAP and CFtot were quantitatively comparable after either the intravenous or intracarotid administration, the effect on regional CBF and CFint was about twice as high after i.car. infusion, indicating a centrally mediated phenomenon underlying this effect on CBF. The increase in CFint cannot in itself be ascribed to a gamma 2-MSH-mediated higher perfusion pressure (i.e., BP), since an equipressor dose of norepinephrine (NE) caused a significant decrease in CFint. The significant and more than twofold higher increase in CBF after intracarotid administration of gamma 2-MSH in comparison with administration of NE by the same route also suggests a central origin for the enhancement of microcirculatory flow due to the peptide.
Authors:
D J de Wildt; C M Kasbergen; D H Versteeg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  25     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-905     Citation Subset:  IM    
Affiliation:
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Medical Faculty, Utrecht University, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Gas Analysis
Blood Pressure / drug effects*
Carotid Arteries / drug effects,  physiology
Cerebrovascular Circulation / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects*
Injections, Intra-Arterial
Injections, Intravenous
Laser-Doppler Flowmetry
Male
Melanocyte-Stimulating Hormones / administration & dosage,  pharmacology*
Norepinephrine / pharmacology
Rats
Rats, Wistar
Regional Blood Flow / drug effects
Vasoconstrictor Agents / pharmacology
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 9002-79-3/Melanocyte-Stimulating Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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