Document Detail

Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats.
MedLine Citation:
PMID:  17928644     Owner:  NLM     Status:  MEDLINE    
Substance P (SP), vasoactive intestinal polypeptide (VIP) and galanin (GAL), present in primary sensory neurons, are involved in transmission of nociceptive signaling from the peripheral to central nervous system. In this study we investigated the effect of GAL on SP-induced or VIP-induced evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation during perfusion of the cerebral ventricles with SP or VIP solutions. The experiments were carried out on rats under chloralose anesthesia. It was shown that both, SP and VIP, perfused through the cerebral ventricles enhanced the ETJ amplitude as compared with control, but the effect produced by SP was stronger. The intracerebroventricular perfusion of GAL 5 minutes before SP caused a dose-dependent inhibition of SP-induced ETJ, whereas GAL perfused through the cerebral ventricles 5 minutes before VIP did not reduce the excitatory effect of VIP on ETJ. These results indicate that the antinociceptive effect of GAL perfused through the cerebral ventricles, tested on the trigemino-hypoglossal reflex in rats, is specifically mediated by the SP-ergic system.
M Zubrzycka; A Janecka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  58     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Department of Experimental Physiology, Medical University, Lodz, Poland.
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MeSH Terms
Anesthesia / methods
Cerebral Ventricles / drug effects
Chloralose / administration & dosage
Dental Pulp / innervation
Dose-Response Relationship, Drug
Electric Stimulation
Galanin / pharmacology*
Hypoglossal Nerve / physiology
Nociceptors / physiology
Perfusion / methods
Rats, Long-Evans
Reflex / drug effects*,  physiology
Stereotaxic Techniques / instrumentation
Substance P / pharmacology*
Time Factors
Tongue / innervation
Trigeminal Nerve / physiology
Vasoactive Intestinal Peptide / pharmacology*
Reg. No./Substance:
15879-93-3/Chloralose; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 88813-36-9/Galanin

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