| Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats. | |
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MedLine Citation:
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PMID: 17928644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Substance P (SP), vasoactive intestinal polypeptide (VIP) and galanin (GAL), present in primary sensory neurons, are involved in transmission of nociceptive signaling from the peripheral to central nervous system. In this study we investigated the effect of GAL on SP-induced or VIP-induced evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation during perfusion of the cerebral ventricles with SP or VIP solutions. The experiments were carried out on rats under chloralose anesthesia. It was shown that both, SP and VIP, perfused through the cerebral ventricles enhanced the ETJ amplitude as compared with control, but the effect produced by SP was stronger. The intracerebroventricular perfusion of GAL 5 minutes before SP caused a dose-dependent inhibition of SP-induced ETJ, whereas GAL perfused through the cerebral ventricles 5 minutes before VIP did not reduce the excitatory effect of VIP on ETJ. These results indicate that the antinociceptive effect of GAL perfused through the cerebral ventricles, tested on the trigemino-hypoglossal reflex in rats, is specifically mediated by the SP-ergic system. |
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Authors:
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M Zubrzycka; A Janecka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 58 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-11 Completed Date: 2007-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 479-86 Citation Subset: IM |
Affiliation:
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Department of Experimental Physiology, Medical University, Lodz, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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methods Animals Cerebral Ventricles / drug effects Chloralose / administration & dosage Dental Pulp / innervation Dose-Response Relationship, Drug Electric Stimulation Galanin / pharmacology* Hypoglossal Nerve / physiology Male Nociceptors / physiology Perfusion / methods Rats Rats, Long-Evans Reflex / drug effects*, physiology Stereotaxic Techniques / instrumentation Substance P / pharmacology* Time Factors Tongue / innervation Trigeminal Nerve / physiology Vasoactive Intestinal Peptide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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15879-93-3/Chloralose; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 88813-36-9/Galanin |
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