Document Detail


The Effect of gadolinium on the ESR response of alanine and ammonium tartrate exposed to thermal neutrons.
MedLine Citation:
PMID:  18220469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many efforts have been made to develop neutron capture therapy (NCT) for cancer treatment. Among the challenges in using NCT is the characterization of the features of the mixed radiation field and of its components. In this study, we examined the enhancement of the ESR response of pellets of alanine and ammonium tartrate with gadolinium oxide exposed to a thermal neutron beam. In particular, the ESR response of these dosimeters as a function of the gadolinium content inside the dosimeter was analyzed. We found that the addition of gadolinium improves the sensitivity of both alanine and ammonium tartrate. However, the use of gadolinium reduces or abolishes tissue equivalence because of its high atomic number (Z(Gd) = 64). Therefore, it is necessary to find the optimum compromise between the sensitivity to thermal neutrons and the reduction of tissue equivalence. Our analysis showed that a low concentration of gadolinium oxide (of the order of 5% of the total mass of the dosimeter) can enhance the thermal neutron sensitivity more than 13 times with an insignificant reduction of tissue equivalence.
Authors:
Maurizio Marrale; Maria Brai; Gaetano Gennaro; Antonio Bartolotta; Maria Cristina D'Oca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiation research     Volume:  169     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-03-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-9     Citation Subset:  IM; S    
Affiliation:
Dipartimento di Fisica e Tecnologie Relative, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy. marrale@difter.unipa.it
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MeSH Terms
Descriptor/Qualifier:
Alanine / chemistry,  radiation effects*
Dose-Response Relationship, Radiation
Electron Spin Resonance Spectroscopy / methods*
Gadolinium / chemistry,  radiation effects*
Hot Temperature
Neutrons*
Radiation Dosage
Radiometry / methods*
Reproducibility of Results
Sensitivity and Specificity
Tartrates / chemistry,  radiation effects*
Chemical
Reg. No./Substance:
0/Tartrates; 526-83-0/tartaric acid; 56-41-7/Alanine; 7440-54-2/Gadolinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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