Document Detail


Effect of fusidic acid on pancreatic islet allograft rejection.
MedLine Citation:
PMID:  9040954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined in fully mismatched rats, the survival of pancreatic islet allografts in recipients treated with either fusidic acid (FA), an antistaphyllococcal antibiotic that has been shown to possess an immunosuppressive effect in vitro and in vivo, or cyclosporin-A (CsA). Islets were isolated by collagenase digestion, separated from acinar tissue by handpicking under a dissecting microscope and transplanted into the liver by portal vein injection of streptozotocin(STZ)-induced diabetic rats. The results indicated that while a temporary immunosuppression with CsA achieved an indefinite islet allograft survival, FA administered to recipients daily was not able to prevent islet allograft rejection across a major histocompatibility barrier. We conclude that despite the fact that fusidic acid has been claimed to act as an-immunosuppressant drug in vitro with effects similar to those of CsA, unlike CsA, FA given either orally or by s.c. injection was not effective to prolong islet allograft survival in vivo.
Authors:
J F Mendola; H Corominola; E Esmatjes; A Saenz; L Fernandez-Cruz; R Gomis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell transplantation     Volume:  6     ISSN:  0963-6897     ISO Abbreviation:  Cell Transplant     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-06-17     Completed Date:  1997-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Affiliation:
Department of Surgery, Hospital Clínic of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / pharmacology*
Fusidic Acid / pharmacology*
Graft Rejection / metabolism*
Immunity, Cellular / drug effects
Immunosuppressive Agents / pharmacology
Islets of Langerhans Transplantation*
Rats
Rats, Inbred Lew
Rats, Wistar
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Immunosuppressive Agents; 6990-06-3/Fusidic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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