| Effect of furosemide on thoracic duct lymph flow in the dog. | |
| | |
MedLine Citation:
|
PMID: 7377348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Furosemide 20 mg/kg was given intravenously to 12 anesthetized dogs with clamped renal pedicles. Thoracic duct lymph flow (TDLF) increased promptly by 38% (P less than 0.05), an increment that lasted 80 min. Because in 6 of 12 dogs there was a transient increase in splanchnic blood flow, in separate groups splanchnic blood flow was either markedly constricted or markedly increased by intravenous isoproterenol. Thoracic duct lymph flow increased by 95 and 90%, respectively, following furosemid despite no further change in splanchnic blood flow. Furosemide had no effect on blood pressure, lymph protein, or plasma sodium. In four chronic caval dogs, TDLF was increased by 400%, yet furosemide produced a further increment in lymph flow of 30% (P less than 0.05). Infusion of a 25% albumin solution to contract the interstitial fluid did not abolish the furosemide effect, but a 10% mannitol solution did. Furosemide increased TDLF even after the infusion of papaverine reduced blood pressure to 60 mmHg. We conclude that furosemide increases TDLF by acting directly on splanchnic capillaries to allow increased filtration of fluid in the absence of increased splanchnic blood flow or capillary hydrostatic pressure. |
| | |
Authors:
|
C McCaffrey; M Levy |
Related Documents
:
|
22531338 - Transfusion of stored autologous blood does not alter reactive hyperemia index in healt... 835698 - Interactions of intestinal lymph flow and secretion. 8101368 - Vasodilator effect of pituitary adenylate cyclase activating polypeptide (pacap) on fem... 2928 - Canine cardiac lymph potassium, ph and flow after experimental myocardial infarction. 3250418 - Effect of general anaesthesia on transient lower oesophageal sphincter relaxations in t... 931908 - Adrenergic receptors and vascular resistance in cerebral circulation of the cat. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 238 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1980 May |
Date Detail:
|
Created Date: 1980-07-28 Completed Date: 1980-07-28 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: F363-71 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdomen
/
blood supply Angiotensin II / pharmacology Animals Blood Proteins / physiology Calcium / pharmacology Dogs Extracellular Space / physiology Female Furosemide / pharmacology* Isoproterenol / pharmacology Kidney / physiology Lymph / physiology* Male Papaverine / pharmacology Regional Blood Flow / drug effects Saralasin / pharmacology Sodium Nitrite / pharmacology Thoracic Duct / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 54-31-9/Furosemide; 58-74-2/Papaverine; 7440-70-2/Calcium; 7632-00-0/Sodium Nitrite; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phosphate transport by isolated rabbit cortical collecting tubule.
Next Document: Relation of Na+ reabsorption to utilization of O2 and lactate in the perfused rat kidney.