Document Detail

Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses.
MedLine Citation:
PMID:  19881919     Owner:  NLM     Status:  MEDLINE    
The objective was to quantify the effect of furosemide and carbazochrome on exercise-induced pulmonary hemorrhage (EIPH) in Standardbred horses using red blood cell count and hemoglobin concentration in bronchoalveolar lavage (BAL) fluid. Six healthy Standardbred horses with prior evidence of EIPH performed a standardized treadmill test 4 h after administration of placebo, furosemide, or furosemide-carbazochrome combination. Red blood cell (RBC) counts and hemoglobin concentrations were determined on the BAL fluid. The RBC count in BAL ranges were (2903-26,025 cells/microL), (45-24,060 cells/microL), and (905-3045 cells/microL) for placebo, furosemide, and furosemide-carbazochrome, respectively. Hemoglobin concentration ranges were (0.03-0.59 mg/mL), (0.01-0.55 mg/mL), and (0.007-0.16 mg/mL) for placebo, furosemide, and furosemide-carbazochrome groups, respectively. No significant differences were detected among treatments. However, there was great variability among horses, suggesting that a larger sample size or better selection of horses was needed.
Cecilia I Perez-Moreno; Laurent L Couëtil; Suzanne M Pratt; Hugo G Ochoa-Acuña; Rose E Raskin; Mark A Russell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian veterinary journal. La revue vétérinaire canadienne     Volume:  50     ISSN:  0008-5286     ISO Abbreviation:  Can. Vet. J.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-13     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0004653     Medline TA:  Can Vet J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  821-7     Citation Subset:  IM    
Animal Science, Purdue University, West Lafayette, Indiana 47906, USA.
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MeSH Terms
Adrenochrome / analogs & derivatives*,  therapeutic use
Bronchoalveolar Lavage Fluid / cytology
Cross-Over Studies
Diuretics / therapeutic use*
Drug Therapy, Combination
Exercise Test / veterinary
Furosemide / therapeutic use*
Hemorrhage / drug therapy,  veterinary*
Horse Diseases / drug therapy*
Lung Diseases / drug therapy,  veterinary*
Physical Conditioning, Animal / adverse effects*
Random Allocation
Treatment Outcome
Reg. No./Substance:
0/Diuretics; 54-06-8/Adrenochrome; 54-31-9/Furosemide; 81F061RQS4/carbazochrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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