| Effect of frusemide on urinary kallikrein excretion in the conscious rat: influence of adrenalectomy and DOCA treatment. | |
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MedLine Citation:
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PMID: 3375289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of subcutaneous frusemide administration on urinary kallikrein excretion was studied in the conscious state, in control, adrenalectomized and DOCA-treated adrenalectomized rats. Frusemide increased urinary kallikrein excretion in the three groups of rats. Urine volume and urinary sodium and potassium excretions were also increased. These responses were however suppressed by adrenalectomy but normalized by DOCA treatment. It is concluded that frusemide's stimulation of urinary kallikrein excretion in the conscious rat is modulated by mineralocorticoid activity. |
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Authors:
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L F Obika; B S Amurawaiye; E Etok-Akpan; S O Oduleye |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacological research communications Volume: 20 ISSN: 0031-6989 ISO Abbreviation: Pharmacol Res Commun Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-07-01 Completed Date: 1988-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236354 Medline TA: Pharmacol Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 49-59 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biochemistry, University of Ilorin, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy* Animals Desoxycorticosterone / pharmacology* Furosemide / pharmacology* Kallikreins / urine* Male Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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54-31-9/Furosemide; 64-85-7/Desoxycorticosterone; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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