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Effect of fresh human amniotic membrane dressing on graft take in patients with chronic burn wounds compared with conventional methods.
MedLine Citation:
PMID:  22951345     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Burns are among the most devastating forms of injury. Nowadays the standard treatment for deep partial thickness and full-thickness burn is early excision and grafting, but this technique is not always feasible; and this leads to chronicity and microbial colonization of burn wounds. Interesting properties of human amniotic membrane made us use it in management of chronic infected burn wounds. METHODS: From January 2008 to September 2010, in a prospective clinical trail, 38 patients (76 limbs) with symmetric chronic burn wounds in both upper or lower limbs included in this study. Tissue cultures were taken from all the wounds. For the right, after debridement of granulation tissue and meshed split thickness skin grafting, the graft surfaces were covered with amniotic membrane dressing and in left limb wounds, after debridement, skin grafting was done in conventional method. 21days later, the success rate of graft take was compared between two groups. RESULTS: The study group was composed of 76 limbs in 38 patients with mean age of 27.18±6.38 and burn in 29.18±7.23 TBSA%. The most common causes of the burn wounds chronicity in the selected patients was delayed admission due to poor compliance of the patients (44.8%). Staphylococcus was the most frequent isolate in wounds in our patients (62.85%). Mean graft take was observed in 90.13% of right upper limbs, and 67.36% of left upper limbs; which was significantly different (P<0.001). CONCLUSIONS: Our study showed that human amniotic membrane dressing significantly increases the success rate of graft take in chronic wounds, and it can be recommended as an important dressing in chronic burn wounds management, due to interesting anti-microbial, and better graft take effects.
Authors:
Ali Akbar Mohammadi; Seyed Morteza Seyed Jafari; Mandana Kiasat; Ahmad Reza Tavakkolian; Mohammad Taghi Imani; Mehdi Ayaz; Hamid Reza Tolide-Ie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  -     ISSN:  1879-1409     ISO Abbreviation:  Burns     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.
Affiliation:
Shiraz Burn Research Centre, Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Iran.
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