| Effect on free radical generation with different anaesthesia. | |
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MedLine Citation:
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PMID: 17824463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species are a part of the normal physiology of the biological system but their subsequent defence undergoes alteration during diseased conditions. Administration of anaesthesia for surgery may also alter the formation of reactive oxygen species. The present work deals with the comparative status of oxidative stress (lipid peroxidation) and anti-oxidant defence markers (superoxide dismutase and catalase) in blood in 3 groups of 15 patients each receiving halothane, relaxant vecuronium and spinal form of anaesthesia with lignocaine 5% heavy. The results obtained depict that the formation of malonyl dialdehyde as well as decrease in superoxide dismutase and catalase activities was highest in spinal anaesthesia followed by halothane and then relaxant group. Therefore, it seems important to consider the pre-operative anti-oxidant status while administering anaesthesia to such patients in order to provide biologically safe anaesthesia. |
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Authors:
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Jaishri Bogra; R Gangoo; V C Pandey; Pratima Srivastava |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the Indian Medical Association Volume: 105 ISSN: 0019-5847 ISO Abbreviation: J Indian Med Assoc Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-09-10 Completed Date: 2007-10-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505608 Medline TA: J Indian Med Assoc Country: India |
Other Details:
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Languages: eng Pagination: 128-9, 132 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, King George's Medical College, Lucknow 226003. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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adverse effects* Anesthesia, Spinal / adverse effects Biological Markers / blood Catalase / blood* Female Halothane / adverse effects Humans Lidocaine / adverse effects Lipid Peroxidation* Male Neuromuscular Nondepolarizing Agents / adverse effects Oxidative Stress* Reactive Oxygen Species / blood* Superoxide Dismutase / blood* Vecuronium Bromide / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Neuromuscular Nondepolarizing Agents; 0/Reactive Oxygen Species; 137-58-6/Lidocaine; 151-67-7/Halothane; 50700-72-6/Vecuronium Bromide; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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