| Effect of free dietary glutamate on gastric secretion in dogs. | |
| | |
MedLine Citation:
|
PMID: 19686114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The amino acid, L-glutamate, which is abundant in many foodstuffs, is a potent stimulator of gastric vagal afferents. The aim of the study was to evaluate a role of dietary glutamate in neuroendocrine control of gastric secretion of acid, pepsinogen, and fluid. In mongrel dogs with small gastric pouches surgically prepared according to Pavlov (vagally innervated) or Heidenhain (vagally decentralized), secretion in a pouch was induced by infusion into the main stomach of an amino acid-rich diet lacking glutamate (Elental) or the same diet supplemented with monosodium glutamate (MSG). Having no effect alone, MSG (100 mM) potentiated secretion induced by Elental both in Pavlov and Heidenhain models. In the Pavlov pouch, the effect of MSG was markedly reduced after i.v. injection of granisetron, an antagonist of 5-HT(3) receptors. In the Heidenhain model, MSG enhanced the stimulatory effect of pentagastrin (1 microg/kg, s.c.). In conclusion, dietary glutamate at doses not exceeding its common concentrations in foods substantially potentiates gastric phase secretion induced by stimulation of gastric mucosa with an amino acid-rich diet or by administration of pentagastrin. The effect of glutamate is partially mediated via serotonin secretion and stimulation of 5-HT(3) receptors. |
| | |
Authors:
|
Vasiliy Zolotarev; Raisa Khropycheva; Hisayuki Uneyama; Kunio Torii |
Related Documents
:
|
12784 - Studies on lipid digestion in the preruminant calf. the source of lipolytic activity in... 3304754 - How do non-steroidal anti-inflammatory drugs affect gastric mucosal defenses? 6272324 - Properties of the gastric proton pump in unstimulated permeable gastric glands. 6705644 - Glucose perfusion intragastric titration. 9461674 - Heat shock treatment releases penicillium phosphoglycopeptide. 2561244 - Role, mechanism of action and application of gonadoliberins in reproductive processes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of the New York Academy of Sciences Volume: 1170 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-08-18 Completed Date: 2009-09-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 87-90 Citation Subset: IM |
Affiliation:
|
Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint-Petersburg, Russia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diet* Dogs Female Gastric Acid / secretion* Gastric Mucosa / drug effects*, secretion Glutamic Acid / administration & dosage, pharmacology* Granisetron / administration & dosage Injections, Intravenous Male Models, Biological Pentagastrin / administration & dosage Serotonin Antagonists / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Antagonists; 109889-09-0/Granisetron; 5534-95-2/Pentagastrin; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical trial of glutamate for the improvement of nutrition and health in the elderly.
Next Document: T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.