Document Detail

Effect of free dietary glutamate on gastric secretion in dogs.
MedLine Citation:
PMID:  19686114     Owner:  NLM     Status:  MEDLINE    
The amino acid, L-glutamate, which is abundant in many foodstuffs, is a potent stimulator of gastric vagal afferents. The aim of the study was to evaluate a role of dietary glutamate in neuroendocrine control of gastric secretion of acid, pepsinogen, and fluid. In mongrel dogs with small gastric pouches surgically prepared according to Pavlov (vagally innervated) or Heidenhain (vagally decentralized), secretion in a pouch was induced by infusion into the main stomach of an amino acid-rich diet lacking glutamate (Elental) or the same diet supplemented with monosodium glutamate (MSG). Having no effect alone, MSG (100 mM) potentiated secretion induced by Elental both in Pavlov and Heidenhain models. In the Pavlov pouch, the effect of MSG was markedly reduced after i.v. injection of granisetron, an antagonist of 5-HT(3) receptors. In the Heidenhain model, MSG enhanced the stimulatory effect of pentagastrin (1 microg/kg, s.c.). In conclusion, dietary glutamate at doses not exceeding its common concentrations in foods substantially potentiates gastric phase secretion induced by stimulation of gastric mucosa with an amino acid-rich diet or by administration of pentagastrin. The effect of glutamate is partially mediated via serotonin secretion and stimulation of 5-HT(3) receptors.
Vasiliy Zolotarev; Raisa Khropycheva; Hisayuki Uneyama; Kunio Torii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1170     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
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MeSH Terms
Gastric Acid / secretion*
Gastric Mucosa / drug effects*,  secretion
Glutamic Acid / administration & dosage,  pharmacology*
Granisetron / administration & dosage
Injections, Intravenous
Models, Biological
Pentagastrin / administration & dosage
Serotonin Antagonists / administration & dosage
Reg. No./Substance:
0/Serotonin Antagonists; 109889-09-0/Granisetron; 5534-95-2/Pentagastrin; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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