| Effect of free fatty acids on bilirubin-albumin binding affinity and unbound bilirubin in premature infants. | |
| | |
MedLine Citation:
|
PMID: 20631387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The author has previously shown that intravenous lipid intake may be associated with an increase in unbound bilirubin in infants < or =28 weeks gestational age. The objective of this study was to evaluate whether this increase in unbound bilirubin is mediated by free fatty acids and to examine the secondary effect of free fatty acids on bilirubin-albumin binding affinity. METHODS: A prospective study was conducted to include 26 infants < or =32 weeks gestational age with indirect hyperbilirubinemia and receiving intravenous lipids during the first 10 postnatal days. Blood samples were collected for unbound bilirubin, binding affinity, and free fatty acid measurement at varying intravenous lipid intakes (1-3 g/kg/d). Regression analyses were performed to evaluate the roles of free fatty acids and binding affinity as mediators. RESULTS: Intravenous lipid intake was significantly associated with an increase in free fatty acids and unbound bilirubin in infants < or =28 weeks but not >28 weeks gestational age. In infants < or =28 weeks gestational age, each unit increase in free fatty acids was significantly associated with a decrease in binding affinity, which was significantly associated with an increase in unbound bilirubin. CONCLUSIONS: In infants < or =28 weeks gestational age, intravenous lipid intake may be associated with an increase in unbound bilirubin, and this is mediated by an increase in free fatty acids and a secondary decrease in binding affinity. In infants >28 weeks gestational age, higher intravenous lipid intake may be used because it is unassociated with increases in free fatty acids and unbound bilirubin. |
| | |
Authors:
|
Sanjiv B Amin |
Related Documents
:
|
10400707 - A convenient oxidation of natural glycosphingolipids to their "ceramide acids" for neog... 14529287 - Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble e... 517647 - Effects of bilirubin on fat cell metabolism and lipolysis. 2248947 - Fatty acid binding sites of rodent adipocyte and heart fatty acid binding proteins: cha... 10817367 - Chiral separation of unmodified amino acids with non-aqueous capillary electrophoresis ... 68427 - Staining mycobacteria with periodic acid-carbol-pararosanilin: principle and practice o... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: JPEN. Journal of parenteral and enteral nutrition Volume: 34 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2010 Jul-Aug |
Date Detail:
|
Created Date: 2010-07-15 Completed Date: 2011-01-26 Revised Date: 2012-01-24 |
Medline Journal Info:
|
Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 414-20 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Division of Neonatology, Golisano Children's Hospital at Strong, University of Rochester, Rochester, New York 14642, USA. Sanjiv_Amin@urmc.rochester.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albumins
/
metabolism* Bilirubin / blood, metabolism* Dietary Fats / administration & dosage* Fat Emulsions, Intravenous Fatty Acids, Nonesterified / blood, pharmacology* Humans Hyperbilirubinemia / blood* Infant, Newborn Infant, Premature / blood* Parenteral Nutrition Prospective Studies Protein Binding Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
|
K-23 DC 006229-04/DC/NIDCD NIH HHS; K23 DC006229-05/DC/NIDCD NIH HHS; UL1 RR 024160/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glutamine supplementation decreases intestinal permeability and preserves gut mucosa integrity in an...
Next Document: Fluoroscopy-guided percutaneous gastrostomy with pull technique for the amyotrophic lateral sclerosi...