Document Detail


Effect of free fatty acids on bilirubin-albumin binding affinity and unbound bilirubin in premature infants.
MedLine Citation:
PMID:  20631387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The author has previously shown that intravenous lipid intake may be associated with an increase in unbound bilirubin in infants < or =28 weeks gestational age. The objective of this study was to evaluate whether this increase in unbound bilirubin is mediated by free fatty acids and to examine the secondary effect of free fatty acids on bilirubin-albumin binding affinity.
METHODS: A prospective study was conducted to include 26 infants < or =32 weeks gestational age with indirect hyperbilirubinemia and receiving intravenous lipids during the first 10 postnatal days. Blood samples were collected for unbound bilirubin, binding affinity, and free fatty acid measurement at varying intravenous lipid intakes (1-3 g/kg/d). Regression analyses were performed to evaluate the roles of free fatty acids and binding affinity as mediators.
RESULTS: Intravenous lipid intake was significantly associated with an increase in free fatty acids and unbound bilirubin in infants < or =28 weeks but not >28 weeks gestational age. In infants < or =28 weeks gestational age, each unit increase in free fatty acids was significantly associated with a decrease in binding affinity, which was significantly associated with an increase in unbound bilirubin.
CONCLUSIONS: In infants < or =28 weeks gestational age, intravenous lipid intake may be associated with an increase in unbound bilirubin, and this is mediated by an increase in free fatty acids and a secondary decrease in binding affinity. In infants >28 weeks gestational age, higher intravenous lipid intake may be used because it is unassociated with increases in free fatty acids and unbound bilirubin.
Authors:
Sanjiv B Amin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  34     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-15     Completed Date:  2011-01-26     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Albumins / metabolism*
Bilirubin / blood,  metabolism*
Dietary Fats / administration & dosage*
Fat Emulsions, Intravenous
Fatty Acids, Nonesterified / blood,  pharmacology*
Humans
Hyperbilirubinemia / blood*
Infant, Newborn
Infant, Premature / blood*
Parenteral Nutrition
Prospective Studies
Protein Binding
Regression Analysis
Grant Support
ID/Acronym/Agency:
K-23 DC 006229-04/DC/NIDCD NIH HHS; K23 DC006229/DC/NIDCD NIH HHS; K23 DC006229-05/DC/NIDCD NIH HHS; UL1 RR 024160/RR/NCRR NIH HHS; UL1 RR024160/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; RFM9X3LJ49/Bilirubin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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