Document Detail


Effect of a fortified maize-meal porridge on anemia, micronutrient status, and motor development of infants.
MedLine Citation:
PMID:  16280435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Maize-meal porridge is used for infant feeding in many African countries, including South Africa. A low-cost, finely milled, maize-meal porridge was fortified with beta-carotene, iron, and zinc (100% of recommended dietary allowance), as well as ascorbic acid, copper, selenium, riboflavin, vitamin B-6, vitamin B-12, and vitamin E. OBJECTIVE: We assessed whether the fortified porridge could reduce anemia and improve the micronutrient status and motor development of infants. DESIGN: Infants aged 6-12 mo (n = 361) were randomly assigned to receive either the fortified or unfortified porridge for 6 mo. Primary outcomes were hemoglobin and serum retinol, zinc, and ferritin concentrations and motor development. Growth was assessed as a secondary outcome. Primary and secondary outcomes were assessed at baseline and 6 mo. RESULTS: Two hundred ninety-two infants completed the study. The fortified-porridge group had an intervention effect of 9.4 microg/L (95% CI: 3.6, 15.1 microg/L) for serum ferritin and 9 g/L (95% CI: 6, 12 g/L) for hemoglobin concentrations. The proportion of infants with anemia decreased from 45% to 17% in the fortified-porridge group, whereas it remained >40% in the control group. The fortified-porridge group achieved on average 15.5 of the 25 motor development score items, whereas the control group achieved 14.4 items (P = 0.007). Serum retinol concentration showed an inconsistent effect, and no intervention effect was observed for serum zinc concentrations. CONCLUSIONS: This low-cost fortified porridge can potentially have a significant effect in reducing anemia and improving iron status and motor development of infants in poor settings. The formulation needs some adjustment in terms of zinc fortification.
Authors:
Mieke Faber; Jane D Kvalsvig; Carl J Lombard; A J Spinnler Benadé
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  82     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-10     Completed Date:  2005-12-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1032-9     Citation Subset:  AIM; IM    
Affiliation:
Nutritional Intervention Research Unit, Medical Research Council, Tygerberg, South Africa. mieke.faber@mrc.ac.za
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / drug therapy*
Ascorbic Acid / administration & dosage
Child Development / drug effects*,  physiology
Copper / administration & dosage
Female
Food, Fortified
Humans
Infant
Infant Food
Infant Nutritional Physiological Phenomena
Iron, Dietary / administration & dosage
Male
Micronutrients / administration & dosage*,  metabolism
Motor Skills / drug effects*,  physiology
Nutritive Value
Selenium / administration & dosage
Vitamin B Complex / administration & dosage
Vitamin E / administration & dosage
Vitamins / administration & dosage*,  metabolism
Weaning*
Zea mays*
Zinc / administration & dosage
beta Carotene / administration & dosage
Chemical
Reg. No./Substance:
0/Iron, Dietary; 0/Micronutrients; 0/Vitamins; 12001-76-2/Vitamin B Complex; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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