| Effect of a fortified maize-meal porridge on anemia, micronutrient status, and motor development of infants. | |
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MedLine Citation:
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PMID: 16280435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Maize-meal porridge is used for infant feeding in many African countries, including South Africa. A low-cost, finely milled, maize-meal porridge was fortified with beta-carotene, iron, and zinc (100% of recommended dietary allowance), as well as ascorbic acid, copper, selenium, riboflavin, vitamin B-6, vitamin B-12, and vitamin E. OBJECTIVE: We assessed whether the fortified porridge could reduce anemia and improve the micronutrient status and motor development of infants. DESIGN: Infants aged 6-12 mo (n = 361) were randomly assigned to receive either the fortified or unfortified porridge for 6 mo. Primary outcomes were hemoglobin and serum retinol, zinc, and ferritin concentrations and motor development. Growth was assessed as a secondary outcome. Primary and secondary outcomes were assessed at baseline and 6 mo. RESULTS: Two hundred ninety-two infants completed the study. The fortified-porridge group had an intervention effect of 9.4 microg/L (95% CI: 3.6, 15.1 microg/L) for serum ferritin and 9 g/L (95% CI: 6, 12 g/L) for hemoglobin concentrations. The proportion of infants with anemia decreased from 45% to 17% in the fortified-porridge group, whereas it remained >40% in the control group. The fortified-porridge group achieved on average 15.5 of the 25 motor development score items, whereas the control group achieved 14.4 items (P = 0.007). Serum retinol concentration showed an inconsistent effect, and no intervention effect was observed for serum zinc concentrations. CONCLUSIONS: This low-cost fortified porridge can potentially have a significant effect in reducing anemia and improving iron status and motor development of infants in poor settings. The formulation needs some adjustment in terms of zinc fortification. |
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Authors:
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Mieke Faber; Jane D Kvalsvig; Carl J Lombard; A J Spinnler Benadé |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 82 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-10 Completed Date: 2005-12-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1032-9 Citation Subset: AIM; IM |
Affiliation:
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Nutritional Intervention Research Unit, Medical Research Council, Tygerberg, South Africa. mieke.faber@mrc.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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drug therapy* Ascorbic Acid / administration & dosage Child Development / drug effects*, physiology Copper / administration & dosage Female Food, Fortified Humans Infant Infant Food Infant Nutritional Physiological Phenomena Iron, Dietary / administration & dosage Male Micronutrients / administration & dosage*, metabolism Motor Skills / drug effects*, physiology Nutritive Value Selenium / administration & dosage Vitamin B Complex / administration & dosage Vitamin E / administration & dosage Vitamins / administration & dosage*, metabolism Weaning* Zea mays* Zinc / administration & dosage beta Carotene / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Iron, Dietary; 0/Micronutrients; 0/Vitamins; 12001-76-2/Vitamin B Complex; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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