Document Detail


Effect of fortification with multiple micronutrients and n-3 fatty acids on growth and cognitive performance in Indian schoolchildren: the CHAMPION (Children's Health and Mental Performance Influenced by Optimal Nutrition) Study.
MedLine Citation:
PMID:  19369376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fortification with multiple micronutrients has been shown to improve growth and cognitive performance among children in developing countries, but it is unknown whether higher concentrations are more effective than lower concentrations. OBJECTIVE: We compared the effect of 2 different concentrations of a combination of micronutrients and n-3 (omega-3) fatty acids on indicators of growth and cognitive performance in low-income, marginally nourished schoolchildren in Bangalore, India. DESIGN: In a 2-by-2 factorial, double-blind, randomized controlled trial, 598 children aged 6-10 y were individually allocated to 1 of 4 intervention groups to receive foods fortified with either 100% or 15% of the Recommended Dietary Allowance of micronutrients in combination with either 900 mg alpha-linolenic acid plus 100 mg docosahexaenoic acid or 140 mg alpha-linolenic acid for 12 mo. Anthropometric and biochemical assessments were performed at baseline and 12 mo. Cognitive performance was measured at baseline and at 6 and 12 mo. RESULTS: The high micronutrient treatment significantly improved linear growth at 12 mo (0.19 cm; 0.01, 0.36) and short-term memory at 6 mo (0.11 SD; 0.01, 0.20) and was less beneficial on fluid reasoning at 6 (-0.10 SD; -0.17, -0.03) and 12 (-0.12 SD; -0.20, -0.04) mo than was the low micronutrient treatment, whereas no differences were observed on weight, retrieval ability, cognitive speediness, and overall cognitive performance. No significant differences were found between the n-3 treatments. CONCLUSIONS: The high micronutrient treatment was more beneficial for linear growth than was the low micronutrient treatment. However, with some small differential effects, higher micronutrient concentrations were as effective as lower concentrations on cognitive performance. This trial was registered at clinicaltrials.gov as NCT00467909.
Authors:
Sumithra Muthayya; Ans Eilander; Catherine Transler; Tinku Thomas; Henk C M van der Knaap; Krishnamachari Srinivasan; B Jan Willem van Klinken; Saskia J M Osendarp; Anura V Kurpad
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-04-15
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  89     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1766-75     Citation Subset:  AIM; IM    
Affiliation:
Division of Nutrition, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India. sumithra@sjri.res.in
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00467909
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Child
Cognition / drug effects*
Dose-Response Relationship, Drug
Double-Blind Method
Fatty Acids, Omega-3 / administration & dosage,  pharmacology,  therapeutic use*
Food, Fortified*
Growth / drug effects*
Humans
India
Malnutrition / drug therapy*
Memory / drug effects*
Micronutrients / administration & dosage,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Micronutrients

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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