Document Detail

Effect of formula thickened with locust bean gum on gastric emptying in infants.
MedLine Citation:
PMID:  17096718     Owner:  NLM     Status:  MEDLINE    
AIM: We investigated the effects of milk-based formulas thickened with two different concentrations of locust bean gum on gastric emptying in infants with recurrent regurgitation episodes. METHODS: Thirty-nine infants with three or more episodes of regurgitation per day but no complications who were fed mainly with infant formula were studied. We first compared gastric emptying in infants fed with formulas thickened with two different concentrations of locust bean gum (HL-350, 0.35 g/100 mL; HL-450, 0.45 g/100 mL) or a regular formula (HL-00). To evaluate gastric emptying, we measured antral cross-sectional areas ultrasonographically at various time points after feeding. Next, to investigate the clinical effect of thickened formulas on regurgitation episodes, 27 infants with episodes were assigned randomly to receive HL-350 and HL-00 or HL-450 and HL-00 for 1 week each. RESULTS: Antral cross-sectional areas at 60, 90, 120 and 150 min with HL-450, and at 60 min with HL-350, were greater than with HL-00. The median gastric emptying rate at 120 min with HL-450 (52.8%) was lower than with HL-00 (97.9%; P = 0.0019), while HL-350 (80.3%) and HL-00 did not differ significantly. The mean number of regurgitation episodes was significantly smaller when infants were fed with either HL-350 or HL-450 than with HL-00. CONCLUSIONS: HL-450, a thickened formula with typical commercially available concentrations of locust bean gum, slowed gastric emptying in infants with gastroesophageal reflux.
Reiko Miyazawa; Takeshi Tomomasa; Hiroaki Kaneko; Akihiro Morikawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  42     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-13     Completed Date:  2007-02-21     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  808-12     Citation Subset:  IM    
Department of Pediatrics and Developmental Medicine, Gunma University Graduate School, Maebashi, Gunma, Japan.
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MeSH Terms
Galactans / pharmacology*
Gastric Emptying / drug effects,  physiology*
Gastroesophageal Reflux / diet therapy
Infant Formula / chemistry*,  pharmacology*
Infant, Newborn
Mannans / pharmacology*
Plant Gums / pharmacology*
Reg. No./Substance:
0/Galactans; 0/Mannans; 0/Plant Gums; 9000-40-2/locust bean gum

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