| Effect of food withdrawal on arterial blood glucose and plasma 13,14-dihydro-15-keto-prostaglandin F2 alpha concentrations and nocturnal myometrial electromyographic activity in the pregnant rhesus monkey in the last third of gestation: a model for preterm labor? | |
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MedLine Citation:
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PMID: 2929698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant rhesus monkeys were studied between 109 and 149 days of gestation. Food withdrawal for 48 hours (with free access to water) was accompanied by a decrease in maternal whole blood glucose concentration and an increased maternal arterial plasma 13,14-dihydro-15-keto-prostaglandin F2 alpha concentration. On successive nights of the 48-hour period of food withdrawal, there was an increase in the frequency of myometrial contractions as recorded by uterine electromyogram. In the period after food was returned, blood glucose, arterial 13,14-dihydro-15-keto-prostaglandin F2 alpha concentration, and contraction frequency returned to baseline. Because food withdrawal results in the appearance of the nocturnal contraction pattern seen at term, we suggest that this experimental paradigm may be used as a model for preterm labor. |
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Authors:
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Z Binienda; A Massmann; M D Mitchell; R D Gleed; J P Figueroa; P W Nathanielsz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 160 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-21 Completed Date: 1989-04-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 746-50 Citation Subset: AIM; IM |
Affiliation:
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Laboratory for Pregnancy and Newborn Research, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries Blood Glucose / analysis* Circadian Rhythm* Dinoprost / analogs & derivatives*, blood Disease Models, Animal Electromyography Female Food Deprivation / physiology* Macaca mulatta Myometrium / physiology* Obstetric Labor, Premature / blood, physiopathology* Osmolar Concentration Pregnancy Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD-18870/HD/NICHD NIH HHS; HD-20779/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 27376-76-7/15-keto-13,14-dihydroprostaglandin F2alpha; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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