Document Detail

Effect of food withdrawal on arterial blood glucose and plasma 13,14-dihydro-15-keto-prostaglandin F2 alpha concentrations and nocturnal myometrial electromyographic activity in the pregnant rhesus monkey in the last third of gestation: a model for preterm labor?
MedLine Citation:
PMID:  2929698     Owner:  NLM     Status:  MEDLINE    
Pregnant rhesus monkeys were studied between 109 and 149 days of gestation. Food withdrawal for 48 hours (with free access to water) was accompanied by a decrease in maternal whole blood glucose concentration and an increased maternal arterial plasma 13,14-dihydro-15-keto-prostaglandin F2 alpha concentration. On successive nights of the 48-hour period of food withdrawal, there was an increase in the frequency of myometrial contractions as recorded by uterine electromyogram. In the period after food was returned, blood glucose, arterial 13,14-dihydro-15-keto-prostaglandin F2 alpha concentration, and contraction frequency returned to baseline. Because food withdrawal results in the appearance of the nocturnal contraction pattern seen at term, we suggest that this experimental paradigm may be used as a model for preterm labor.
Z Binienda; A Massmann; M D Mitchell; R D Gleed; J P Figueroa; P W Nathanielsz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  160     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-21     Completed Date:  1989-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  746-50     Citation Subset:  AIM; IM    
Laboratory for Pregnancy and Newborn Research, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
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MeSH Terms
Blood Glucose / analysis*
Circadian Rhythm*
Dinoprost / analogs & derivatives*,  blood
Disease Models, Animal
Food Deprivation / physiology*
Macaca mulatta
Myometrium / physiology*
Obstetric Labor, Premature / blood,  physiopathology*
Osmolar Concentration
Time Factors
Grant Support
Reg. No./Substance:
0/Blood Glucose; 27376-76-7/15-keto-13,14-dihydroprostaglandin F2alpha; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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