Document Detail


Effect of food and water deprivation on the parameters of the mouse bone marrow micronucleus test.
MedLine Citation:
PMID:  3945239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study reports the influence of acute starvation on spontaneous and cyclophosphamide (CP) induced micronucleus (MN) frequencies in the bone marrow polychromatic erythrocytes (PCE) of CD-1 mice. Groups of mice (5/sex) were deprived of either food alone or food and water for 0, 24, 48 and 72 h prior to sacrifice. Although there was no evidence of a significant increase in MN-PCE frequencies among the starved groups, a significant depressant effect of starvation on erythropoietic activity was observed. Peak levels of CP-induced (40 mg/kg b.w.) MN-PCE's appeared later in male mice deprived of food and water after treatment compared to mice given food and water ad libitum. The results indicate that starvation is detrimental to bone marrow erythropoiesis and that starvation may alter the response of mice to clastogens.
Authors:
B B Gollapudi; R J Bruce; V A Linscombe; P G Watanabe; A K Sinha
Related Documents :
2802339 - Effect of food deprivation on d-xylose absorption test results in mares.
16478679 - Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regula...
18569769 - Butt lengths differ by area deprivation level: a field study to explore intensive smoking.
8202219 - Restoration of growth hormone secretion in prolonged food-deprived rats depends on the ...
10758299 - Effects of growth on the response of the rabbit patellar tendon to stress shielding: a ...
1977579 - Influence of food deprivation in the rat on hypothalamic expression of growth hormone-r...
16997349 - Bioconcentration, biomagnification and metabolism of 14c-terbutryn and 14c-benzo[a]pyre...
12643649 - Chemical and sensory evaluation of crude oil extracted from herring byproducts from dif...
17894159 - Nutritional status of vitamin a in morbid obesity before and after roux-en-y gastric by...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  173     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-13     Completed Date:  1986-03-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow / drug effects
Cell Nucleus / drug effects*
Cyclophosphamide / toxicity
Dose-Response Relationship, Drug
Erythrocytes, Abnormal
Female
Food Deprivation
Male
Mice
Mutagenicity Tests / standards*
Water Deprivation
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tissue-specific clastogenic effects of chromium and selenium salts in vivo.
Next Document:  Folic acid and chromosome breakage. III. Types and frequencies of spontaneous chromosome aberrations...