| Effect of food and water deprivation on the parameters of the mouse bone marrow micronucleus test. | |
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MedLine Citation:
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PMID: 3945239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study reports the influence of acute starvation on spontaneous and cyclophosphamide (CP) induced micronucleus (MN) frequencies in the bone marrow polychromatic erythrocytes (PCE) of CD-1 mice. Groups of mice (5/sex) were deprived of either food alone or food and water for 0, 24, 48 and 72 h prior to sacrifice. Although there was no evidence of a significant increase in MN-PCE frequencies among the starved groups, a significant depressant effect of starvation on erythropoietic activity was observed. Peak levels of CP-induced (40 mg/kg b.w.) MN-PCE's appeared later in male mice deprived of food and water after treatment compared to mice given food and water ad libitum. The results indicate that starvation is detrimental to bone marrow erythropoiesis and that starvation may alter the response of mice to clastogens. |
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Authors:
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B B Gollapudi; R J Bruce; V A Linscombe; P G Watanabe; A K Sinha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 173 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-13 Completed Date: 1986-03-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 121-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow / drug effects Cell Nucleus / drug effects* Cyclophosphamide / toxicity Dose-Response Relationship, Drug Erythrocytes, Abnormal Female Food Deprivation Male Mice Mutagenicity Tests / standards* Water Deprivation |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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