Document Detail

Effect of food and water deprivation on the parameters of the mouse bone marrow micronucleus test.
MedLine Citation:
PMID:  3945239     Owner:  NLM     Status:  MEDLINE    
This study reports the influence of acute starvation on spontaneous and cyclophosphamide (CP) induced micronucleus (MN) frequencies in the bone marrow polychromatic erythrocytes (PCE) of CD-1 mice. Groups of mice (5/sex) were deprived of either food alone or food and water for 0, 24, 48 and 72 h prior to sacrifice. Although there was no evidence of a significant increase in MN-PCE frequencies among the starved groups, a significant depressant effect of starvation on erythropoietic activity was observed. Peak levels of CP-induced (40 mg/kg b.w.) MN-PCE's appeared later in male mice deprived of food and water after treatment compared to mice given food and water ad libitum. The results indicate that starvation is detrimental to bone marrow erythropoiesis and that starvation may alter the response of mice to clastogens.
B B Gollapudi; R J Bruce; V A Linscombe; P G Watanabe; A K Sinha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  173     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-13     Completed Date:  1986-03-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / drug effects
Cell Nucleus / drug effects*
Cyclophosphamide / toxicity
Dose-Response Relationship, Drug
Erythrocytes, Abnormal
Food Deprivation
Mutagenicity Tests / standards*
Water Deprivation
Reg. No./Substance:

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