Document Detail


Effect of food on kinetics of 8-methoxsalen.
MedLine Citation:
PMID:  759069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kinetics of 8-methoxsalen were studied in 5 healthy subjects under fasting and nonfasting conditions. The plasma concentration-time data could be fitted to a zero order absorption one-compartment model. The area under the curve (AUC) values were higher (p less than 0.05) under nonfasting compared to fasting conditions, indicating higher relative bioavailability of the drug in the presence of food. No significant differences were observed in the lag-time for the start of the absorption, the apparent zero-order absorption rate constant, or the elimination rate constant. It is suggested that the drug should be taken in a standardized way in relation to food during the ultraviolet (UV) light treatment.
Authors:
H Ehrsson; S O Nilsson; M Ehrnebo; I Wallin; G Wennersten
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  25     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Availability
Food*
Humans
Kinetics
Male
Methoxsalen / blood,  metabolism*
Models, Biological
Chemical
Reg. No./Substance:
298-81-7/Methoxsalen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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