| Effect of food on blood hydralazine levels and response in hypertension. | |
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MedLine Citation:
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PMID: 6734044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study with a nonspecific hydralazine assay reported that food increased hydralazine concentrations in plasma. We used a specific HPLC hydralazine assay to determine the effect of food on hydralazine blood levels and hemodynamic responses after oral hydralazine. Six subjects with uncomplicated essential hypertension were given 1 mg/kg hydralazine solution orally on two occasions at least 3 days apart. On 1 study day subjects fasted and on the other they were given a standard meal 45 min before hydralazine. Mean arterial pressure and heart rate were monitored for 2 hr before and for 4 hr after hydralazine and frequent venous blood samples were drawn for hydralazine assay. Hepatic blood flow was estimated by determination of indocyanine green clearance before food, after food, and 30 min after hydralazine. Peak blood hydralazine concentrations fell in all (46.2% +/- 11.5%; means +/- SE) and areas under the blood hydralazine concentration/time curves fell (45.7% +/- 9.5%) after food. This could not be explained by changes in liver blood flow. Food-related reductions in blood levels of hydralazine were associated with reduced vasodepressor effects (41.5% +/- 5.6%). It is possible that food increases intravascular conversion of hydralazine to hydralazine pyruvic acid hydrazone. The reduction in vasodepressor response suggests that patients with hypertension should take hydralazine at a fixed time in relation to meals. |
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Authors:
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A M Shepherd; N A Irvine; T M Ludden |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 36 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-08-13 Completed Date: 1984-08-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 14-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Blood Pressure / drug effects Chromatography, High Pressure Liquid Female Food* Heart Rate / drug effects Humans Hydralazine / blood*, therapeutic use Hypertension / drug therapy Indocyanine Green / metabolism Liver / blood supply, drug effects Male Middle Aged Phenotype |
| Grant Support | |
ID/Acronym/Agency:
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RR-01346/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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3599-32-4/Indocyanine Green; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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