Document Detail

Effect of food on bioavailability of chloroquine.
MedLine Citation:
PMID:  7173297     Owner:  NLM     Status:  MEDLINE    
The bioavailability of chloroquine in 7 healthy adult and volunteers was assessed with and without a standard breakfast. Chloroquine (600 mg base) was administered orally and timed blood samples were obtained for determination of plasma concentrations. The results suggest that the AUC and peak plasma levels were significantly higher when chloroquine was administered together with food, although the rate of absorption was not different. It appears, therefore, that food facilitates chloroquine absorption and the extent of absorption is significantly modified. Hence administration of chloroquine together with food appears to be an advisable clinical practice.
A Tulpule; K Krishnaswamy
Related Documents :
24420287 - Accelerated food waste composting.
19634347 - Pharmacokinetics of clarithromycin citrate salt after oral administration to beagle dog...
7751427 - Effects of food on the bioequivalence of different verapamil sustained-release formulat...
909397 - Triiodothyronine and thyroxine content of desiccated thyroid tablets.
15914147 - A spectroscopic study of mechanochemically activated kaolinite with the aid of chemomet...
9498697 - Comparative studies on the nutritional and toxic composition of three varieties of lesi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  23     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  271-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Biological Availability
Chloroquine / blood,  metabolism*
Intestinal Absorption*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pharmacokinetics of terodiline in human volunteers.
Next Document:  Plasma high-density lipoproteins and hepatic microsomal enzyme induction. Relation to histological c...