Document Detail


Effect of food on bioavailability of chloroquine.
MedLine Citation:
PMID:  7173297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bioavailability of chloroquine in 7 healthy adult and volunteers was assessed with and without a standard breakfast. Chloroquine (600 mg base) was administered orally and timed blood samples were obtained for determination of plasma concentrations. The results suggest that the AUC and peak plasma levels were significantly higher when chloroquine was administered together with food, although the rate of absorption was not different. It appears, therefore, that food facilitates chloroquine absorption and the extent of absorption is significantly modified. Hence administration of chloroquine together with food appears to be an advisable clinical practice.
Authors:
A Tulpule; K Krishnaswamy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  23     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  271-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Biological Availability
Chloroquine / blood,  metabolism*
Food*
Humans
Intestinal Absorption*
Kinetics
Male
Chemical
Reg. No./Substance:
54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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