Document Detail

Effect of folic acid on nitrate tolerance in healthy volunteers: differences between arterial and venous circulation.
MedLine Citation:
PMID:  12548078     Owner:  NLM     Status:  MEDLINE    
This study investigated whether oral supplemental folic acid can prevent the development of nitrate tolerance and whether it has different effects on the arterial and venous systems. Twenty-four healthy male volunteers received either placebo or folic acid (10 mg/d) for 14 days. Additionally, all subjects underwent concurrent transdermal nitroglycerin therapy for 7 days. Venous occlusion forearm strain gauge plethysmography measured arterial and venous responses to sublingual nitroglycerin before and after treatment. Both arterial and venous responses were blunted in the placebo group after transdermal nitroglycerin. Folic acid prevented the development of nitrate tolerance in arteries but had no effect in veins.
Tommaso Gori; Laura Saunders; Sofia Ahmed; John D Parker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  41     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-27     Completed Date:  2003-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Canada.
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MeSH Terms
Analysis of Variance
Arteries / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Double-Blind Method
Drug Tolerance / physiology*
Folic Acid / pharmacology*
Forearm / blood supply*
Heart Rate / drug effects,  physiology
Nitrates / pharmacology
Nitroglycerin / pharmacology*
Veins / drug effects,  physiology
Reg. No./Substance:
0/Nitrates; 55-63-0/Nitroglycerin; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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