Document Detail


Effect of folic acid on nitrate tolerance in healthy volunteers: differences between arterial and venous circulation.
MedLine Citation:
PMID:  12548078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated whether oral supplemental folic acid can prevent the development of nitrate tolerance and whether it has different effects on the arterial and venous systems. Twenty-four healthy male volunteers received either placebo or folic acid (10 mg/d) for 14 days. Additionally, all subjects underwent concurrent transdermal nitroglycerin therapy for 7 days. Venous occlusion forearm strain gauge plethysmography measured arterial and venous responses to sublingual nitroglycerin before and after treatment. Both arterial and venous responses were blunted in the placebo group after transdermal nitroglycerin. Folic acid prevented the development of nitrate tolerance in arteries but had no effect in veins.
Authors:
Tommaso Gori; Laura Saunders; Sofia Ahmed; John D Parker
Related Documents :
450488 - Venous angioma of the neck in a child.
3627418 - The preoperative venogram in planning extended craniectomies.
6966148 - Endolymphatic hydrops with absence of vein in paravestibular canaliculus.
8036138 - Thrombotic complications of polycythemia. the venous and arterial risk factors.
20058438 - Pulmonary artery laceration by a pulmonary artery catheter: a case report and review of...
10671848 - A new practical classification of laryngeal view.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  41     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-27     Completed Date:  2003-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Arteries / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Double-Blind Method
Drug Tolerance / physiology*
Folic Acid / pharmacology*
Forearm / blood supply*
Heart Rate / drug effects,  physiology
Humans
Male
Nitrates / pharmacology
Nitroglycerin / pharmacology*
Veins / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Nitrates; 55-63-0/Nitroglycerin; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differences between angiotensin-converting enzyme inhibition and angiotensin II-AT1 antagonism on an...
Next Document:  Electrophysiologic characterization of dronedarone in guinea pig ventricular cells.