| Effect of folic acid on nitrate tolerance in healthy volunteers: differences between arterial and venous circulation. | |
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MedLine Citation:
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PMID: 12548078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated whether oral supplemental folic acid can prevent the development of nitrate tolerance and whether it has different effects on the arterial and venous systems. Twenty-four healthy male volunteers received either placebo or folic acid (10 mg/d) for 14 days. Additionally, all subjects underwent concurrent transdermal nitroglycerin therapy for 7 days. Venous occlusion forearm strain gauge plethysmography measured arterial and venous responses to sublingual nitroglycerin before and after treatment. Both arterial and venous responses were blunted in the placebo group after transdermal nitroglycerin. Folic acid prevented the development of nitrate tolerance in arteries but had no effect in veins. |
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Authors:
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Tommaso Gori; Laura Saunders; Sofia Ahmed; John D Parker |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 41 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-27 Completed Date: 2003-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 185-90 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Arteries / drug effects, physiology Blood Pressure / drug effects, physiology Double-Blind Method Drug Tolerance / physiology* Folic Acid / pharmacology* Forearm / blood supply* Heart Rate / drug effects, physiology Humans Male Nitrates / pharmacology Nitroglycerin / pharmacology* Veins / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 55-63-0/Nitroglycerin; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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