Document Detail


Effect of flurazepam on sleep-disordered breathing and nocturnal oxygen desaturation in asymptomatic subjects.
MedLine Citation:
PMID:  7051825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the effect of 30 mg of oral flurazepam on sleep-disordered breathing and nocturnal oxygen desaturation by performing a double-blind, placebo-controlled, randomized study. Asymptomatic subjects, 17 men and three women (mean age 49 years, mean weight 79 kg), were monitored for two consecutive nights. Flurazepam was given to 10 subjects on night 1 and to 10 subjects on night 2. Placebo was ingested on the other nights. Polysomnographic determinations included chest wall movement by impedance pneumography, nasal and oral airflow by thermistor probes, and continuous oxygen saturation by ear oximetry. Flurazepam was associated with significant increases in the number of sleep events (p = 0.01), episodes of apnea (p less than 0.01), and total duration of apnea (p less than 0.01). The number of episodes of hypopnea of desaturation did not significantly increase, although the degree of desaturation increased after flurazepam ingestion (p = 0.04). Total sleep time significantly increased (p = 0.04), but could not account for the increased number of events. Sleep stage distribution was minimally altered by ingestion of flurazepam.
Authors:
F R Dolly; A J Block
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  73     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Clinical Trials as Topic
Double-Blind Method
Female
Flurazepam / adverse effects*
Forced Expiratory Volume
Humans
Male
Middle Aged
Oxygen / blood*
Respiration / drug effects*
Sleep / drug effects,  physiology*
Sleep Apnea Syndromes / physiopathology*
Vital Capacity / drug effects
Grant Support
ID/Acronym/Agency:
HL-22622/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
17617-23-1/Flurazepam; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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