Document Detail


Effect of fluoxetine, pemoline and placebo on heart period and QT variability in normal humans.
MedLine Citation:
PMID:  12932798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To measure the effects of fluoxetine and pemoline on heart period and QT variability. METHODS: Healthy volunteers were randomly assigned treatment with 20 mg daily of fluoxetine (n=7), 56.25 mg of pemoline (n=7) or placebo (n=9). Twenty-four-hour Holter ECGs were obtained before and after approximately 8 weeks of double-blind treatment. RESULTS: There were no significant changes in the fluoxetine group. Pemoline was associated with a significant decrease in the high frequency (HF) power (0.15-0.5 Hz, P=.02) and fractal dimension of RR time series (P=.03). QTvi, a measure of QT interval variability, increased in the pemoline group (P=.05). CONCLUSION: Pemoline, but not fluoxetine, decreases heart period variability (HPV) in the HF power, suggesting a vagolytic effect on cardiac autonomic function. Pemoline is also associated with an increase in QT interval variability, a measure that is sensitive to adrenergic agonists.
Authors:
Robert Pohl; Richard Balon; Anusha Jayaraman; Ronald G Doll; Vikram Yeragani
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of psychosomatic research     Volume:  55     ISSN:  0022-3999     ISO Abbreviation:  J Psychosom Res     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-22     Completed Date:  2004-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376333     Medline TA:  J Psychosom Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2751 E. Jefferson, Detroit, MI 48207, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety Disorders / complications,  drug therapy
Cardiac Output / drug effects*
Central Nervous System Stimulants / pharmacology*
Death, Sudden, Cardiac
Depressive Disorder / complications,  drug therapy
Electroencephalography
Female
Fluoxetine / pharmacology*
Heart Rate / drug effects*
Humans
Male
Pemoline / pharmacology*
Placebos
Serotonin Uptake Inhibitors / pharmacology*
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Placebos; 0/Serotonin Uptake Inhibitors; 2152-34-3/Pemoline; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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