| Effect of fluoride and of calcium sodium phosphosilicate toothpastes on pre-softened dentin demineralization and remineralization in vitro. | |
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MedLine Citation:
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PMID: 20546825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this in vitro study was to evaluate the effect of toothpastes containing sodium fluoride in different concentrations or a calcium sodium phosphosilicate system on pre-softened dentin demineralization and remineralization. METHODS: During a ten day pH-cycling protocol, pre-softened bovine root dentin slabs were immersed twice daily, after the demineralization periods, for 2min, in the following toothpaste slurries: (a) non-fluoridated (control), (b) 7.5% calcium sodium phosphosilicate, (c) 1450 ppm F, (d) 2800 ppm F and (e) 5000 ppm F. Subsequently, the specimens were subjected to a 15-h acid resistance test. Surface microhardness was assessed initially and during the pH-cycling and the acid resistance test period. Repeated measurements in each group were analyzed through appropriate regression models for longitudinal data. RESULTS: All fluoride groups, during pH cycling, showed significantly less microhardness loss (p < or = 0.010, p < or = 0.002, p < or = 0.002) and subsequently exhibited increased acid resistance (p < or = 0.010, p < or = 0.001, p < or = 0.001) compared to the control. The 5000 ppm and 2800 ppm F toothpastes, inhibited demineralization significantly more effectively than the 1450 ppm F (p < or = 0.001, p < or = 0.030) and the calcium sodium phosphosilicate toothpaste (p < or = 0.001), while no significant differences were found between the two high fluoride groups (p=0.130). The calcium sodium phosphosilicate toothpaste, during pH cycling showed a difference that approached statistical significance compared to control (p=0.079), but its acid resistance behavior was similar to control (p=0.610). CONCLUSIONS: Under these experimental conditions, the high fluoride toothpastes promoted remineralization and inhibited demineralization more effectively, than the 1450 ppm F, the non-fluoridated (control) and the calcium sodium phosphosilicate toothpastes. |
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Authors:
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I Diamanti; H Koletsi-Kounari; E Mamai-Homata; G Vougiouklakis |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-06-09 |
Journal Detail:
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Title: Journal of dentistry Volume: 38 ISSN: 1879-176X ISO Abbreviation: J Dent Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354422 Medline TA: J Dent Country: England |
Other Details:
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Languages: eng Pagination: 671-7 Citation Subset: D; IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Preventive and Community Dentistry, University of Athens, Dental School, 2 Thivon St. 115 27, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cariostatic Agents / pharmacology, therapeutic use* Cattle Dentin / drug effects*, pathology Drug Combinations Glass* Hardness / drug effects Hydrogen-Ion Concentration Linear Models Silicates / pharmacology, therapeutic use* Sodium Fluoride / pharmacology, therapeutic use* Tooth Demineralization / prevention & control* Tooth Remineralization / methods* Tooth Root / drug effects, pathology Toothpaste / chemistry, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Cariostatic Agents; 0/Drug Combinations; 0/NovaMin; 0/Silicates; 0/Toothpaste; 7681-49-4/Sodium Fluoride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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