Document Detail

Effect of fluoride and of calcium sodium phosphosilicate toothpastes on pre-softened dentin demineralization and remineralization in vitro.
MedLine Citation:
PMID:  20546825     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this in vitro study was to evaluate the effect of toothpastes containing sodium fluoride in different concentrations or a calcium sodium phosphosilicate system on pre-softened dentin demineralization and remineralization. METHODS: During a ten day pH-cycling protocol, pre-softened bovine root dentin slabs were immersed twice daily, after the demineralization periods, for 2min, in the following toothpaste slurries: (a) non-fluoridated (control), (b) 7.5% calcium sodium phosphosilicate, (c) 1450 ppm F, (d) 2800 ppm F and (e) 5000 ppm F. Subsequently, the specimens were subjected to a 15-h acid resistance test. Surface microhardness was assessed initially and during the pH-cycling and the acid resistance test period. Repeated measurements in each group were analyzed through appropriate regression models for longitudinal data. RESULTS: All fluoride groups, during pH cycling, showed significantly less microhardness loss (p < or = 0.010, p < or = 0.002, p < or = 0.002) and subsequently exhibited increased acid resistance (p < or = 0.010, p < or = 0.001, p < or = 0.001) compared to the control. The 5000 ppm and 2800 ppm F toothpastes, inhibited demineralization significantly more effectively than the 1450 ppm F (p < or = 0.001, p < or = 0.030) and the calcium sodium phosphosilicate toothpaste (p < or = 0.001), while no significant differences were found between the two high fluoride groups (p=0.130). The calcium sodium phosphosilicate toothpaste, during pH cycling showed a difference that approached statistical significance compared to control (p=0.079), but its acid resistance behavior was similar to control (p=0.610). CONCLUSIONS: Under these experimental conditions, the high fluoride toothpastes promoted remineralization and inhibited demineralization more effectively, than the 1450 ppm F, the non-fluoridated (control) and the calcium sodium phosphosilicate toothpastes.
I Diamanti; H Koletsi-Kounari; E Mamai-Homata; G Vougiouklakis
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Journal of dentistry     Volume:  38     ISSN:  1879-176X     ISO Abbreviation:  J Dent     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354422     Medline TA:  J Dent     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  D; IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Preventive and Community Dentistry, University of Athens, Dental School, 2 Thivon St. 115 27, Athens, Greece.
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MeSH Terms
Cariostatic Agents / pharmacology,  therapeutic use*
Dentin / drug effects*,  pathology
Drug Combinations
Hardness / drug effects
Hydrogen-Ion Concentration
Linear Models
Silicates / pharmacology,  therapeutic use*
Sodium Fluoride / pharmacology,  therapeutic use*
Tooth Demineralization / prevention & control*
Tooth Remineralization / methods*
Tooth Root / drug effects,  pathology
Toothpaste / chemistry,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Cariostatic Agents; 0/Drug Combinations; 0/NovaMin; 0/Silicates; 0/Toothpaste; 7681-49-4/Sodium Fluoride

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