Document Detail


Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.
MedLine Citation:
PMID:  12050827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twelve clinically sound, healthy, athletically conditioned Thoroughbred horses were subjected to an incremental exercise stress test to determine the effects and period of detection of a single dose of flunixin meglumine (1.1 mg/kg by intravenous injection) in serum and urine by ELISA. Flunixin concentrations, performance, and hematologic and clinical chemical parameters were measured. All horses were rotated through four treatment groups of a Latin-square design providing for each horse to serve as its own control. Flunixin meglumine reduced prostaglandin F(1alpha) and thromboxane concentrations that had been increased by intense exercise. Performance parameters did not improve and prostaglandin concentrations did not significantly correlate with total run time. Exercise did not change the flunixin elimination profile in either serum or urine, and concentrations were found to be below the detection limit of the ELISA test within 36 hours in serum and 120 hours in urine.
Authors:
Patrick T Colahan; James E Bailey; Chi-Chung Chou; Martha Johnson; Brett L Rice; Galin L Jones; Joseph P Cheeks
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary therapeutics : research in applied veterinary medicine     Volume:  3     ISSN:  1528-3593     ISO Abbreviation:  Vet. Ther.     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-06     Completed Date:  2002-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100936368     Medline TA:  Vet Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-48     Citation Subset:  IM    
Affiliation:
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  blood,  pharmacology*
Blood Glucose
Clonixin / administration & dosage,  analogs & derivatives,  blood,  pharmacology*
Creatinine / blood,  urine
Dinoprostone / blood
Exercise Test / drug effects,  veterinary
Female
Horses / physiology*
Hydrocortisone / blood
Injections, Intravenous / veterinary
Insulin / blood
Male
Oxygen Consumption / drug effects
Physical Conditioning, Animal / physiology*
Prostaglandins / blood
Prostaglandins F / blood
Thromboxane B2 / blood
beta-Endorphin / blood
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Blood Glucose; 0/Prostaglandins; 0/Prostaglandins F; 11061-68-0/Insulin; 17737-65-4/Clonixin; 363-24-6/Dinoprostone; 42461-84-7/flunixin meglumine; 50-23-7/Hydrocortisone; 54397-85-2/Thromboxane B2; 60-27-5/Creatinine; 60617-12-1/beta-Endorphin; 745-62-0/prostaglandin F1; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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