Document Detail


Effect of the fluid-structure interactions on low-density lipoprotein transport within a multi-layered arterial wall.
MedLine Citation:
PMID:  22153222     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The effects of fluid-structure interactions (FSI) and pulsation on the transport of low-density lipoprotein (LDL) through an arterial wall are analyzed in this work. To this end, a comprehensive multi-layer model for both LDL transport as well as fluid-structure interaction (FSI) is introduced. The constructed model is analyzed and compared with the existing results in the limiting cases. Excellent agreement is found between the presented model and the existing results in the limiting cases. The presented model takes into account the complete multi-layered LDL transport while incorporating the FSI aspects to enable a comprehensive study of the deformation effect on the pertinent parameters of the transport processes within an artery. Since the flow inside an artery is time-dependent, the impact of pulsatile flow is also analyzed with and without FSI. A detailed analysis is presented to illustrate the consequence of different factors on the LDL transport in an artery.
Authors:
Stephen Chung; Kambiz Vafai
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-5
Journal Detail:
Title:  Journal of biomechanics     Volume:  -     ISSN:  1873-2380     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Mechanical Engineering, University of California, Riverside (UCR), Riverside, CA 92521, USA.
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