| Effect of fluid and sodium removal on mortality in peritoneal dialysis patients. | |
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MedLine Citation:
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PMID: 11473661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effect of fluid and sodium removal on mortality in peritoneal dialysis patients. BACKGROUND: Adequacy of peritoneal dialysis (PD) traditionally is assessed using Kt/V(urea) and total creatinine clearance (TCC). However, this approach underestimates the importance of fluid and sodium removal. The aim of this study was to determine the effect of fluid and sodium removal on morbidity and mortality in PD patients. METHODS: One hundred twenty-five PD patients were monitored for three years from the beginning of the treatment. The effects of demographic features, comorbidity, peritonitis rate, blood pressure, medications, blood biochemistry, peritoneal membrane transport characteristics, residual renal function (RRF), Kt/V(urea), TCC, normalized protein nitrogen appearance (nPNA), and removal of sodium and fluid on mortality were evaluated. Total and cardiovascular hospitalization rates were also recorded. A Cox proportional hazards model was used to determine factors predicting mortality. RESULTS: In the Cox model, comorbidity, total sodium and fluid removals, hypertensive status, serum creatinine, and RRF were independent factors affecting survival. In contrast, Kt/V(urea) or TCC did not affect the adjusted survivals. Total sodium and fluid removal and hypertensive status also significantly influenced the hospitalization rate. Systolic and diastolic blood pressures were negatively correlated with total fluid (P < 0.001) and sodium removal (P < 0.001). CONCLUSIONS: Together, these findings suggest that removal of sodium and fluid is a predictor of mortality in PD patients, whereas Kt/V(urea) and TCC are not factors. Adequate fluid and sodium balance is crucial for the management of patients on PD. |
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Authors:
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K Ateş; G Nergizoğlu; K Keven; A Sen; S Kutlay; S Ertürk; N Duman; O Karatan; A E Ertuğ |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kidney international Volume: 60 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-27 Completed Date: 2001-10-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 767-76 Citation Subset: IM |
Affiliation:
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Ankara University Medical School, Ibn-i Sina Hospital, Department of Nephrology, Ankara, Turkey. ates@medicine.ankara.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Pressure Body Fluids / metabolism* Creatinine / blood Dialysis Solutions / pharmacokinetics Female Follow-Up Studies Humans Hypertension, Renal / metabolism, mortality, therapy Kidney / physiology Kidney Failure, Chronic / metabolism, mortality*, therapy* Male Middle Aged Peritoneal Dialysis / mortality* Peritoneum / metabolism Proportional Hazards Models Sodium / metabolism* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dialysis Solutions; 60-27-5/Creatinine; 7440-23-5/Sodium |
| Comments/Corrections | |
Comment In:
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Kidney Int. 2002 Apr;61(4):1552
[PMID:
11918771
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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