| Effect of fluid resuscitation on ryanodine receptor in macaques with endotoxic shock. | |
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MedLine Citation:
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PMID: 16762478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our recent study demonstrated that sodium bicarbonate improved cardiac function in macaque models with early-phase endotoxic shock. In the present study, we investigated further the ryanodine receptor/calcium release-channel (RyR) and calcium pump after fluid resuscitation of macaques with early-phase endotoxic shock. METHODS: Twenty-four anaesthetised macaques were assigned to four groups. Nineteen animals were given an intravenous dose of 2.8 mgkg(-1) lipopolysaccharide (LPS). Sixty minutes after the LPS challenge, the animals were given (i) 5 mLkg(-1) normal saline (Ns group, n = 6), (ii) 5 mLkg(-1) of 5% sodium bicarbonate (Sb group, n = 6) or (iii) 5 mLkg(-1) of 3.5% hypertonic sodium chloride (Hs group, n = 7). The control group (Co group, n = 5) received 1 mLkg(-1) normal saline and then with 5 mLkg(-1) normal saline 60 min later. RESULTS: Endotoxin produced a reduction of the density of RyR but did not alter the affinity of RyR. Compared with normal saline, sodium bicarbonate or hypertonic saline induced a restoration of density of RyR but did not influence the affinity of RyR and the calcium pump. CONCLUSION: Up-regulation of RyR performance in myocardium following administration of sodium bicarbonate contributes to the improvement of cardiac function in macaques in the early phase of endotoxic shock. |
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Authors:
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Guo Qing Yin; Xiao Hui Ji; Fei Rong Gu; Cheng Ping Lu; Zhi Xun Fang; Wei Zhao; Yan Chen; Ling Shen; Jia Qi Tang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-09 |
Journal Detail:
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Title: Resuscitation Volume: 70 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-20 Completed Date: 2006-11-20 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Affiliation:
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The Second Hospital of Nanjing, Medical College, Southeast University, 1-1 Zhong-fu Road, Nanjing, Jiangsu 210003, PR China. yinguoq@jlonline.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium-Transporting ATPases / drug effects*, metabolism Disease Models, Animal Escherichia coli Female Fluid Therapy Lipopolysaccharides / administration & dosage Macaca Male Myocardium / metabolism Resuscitation / methods* Ryanodine Receptor Calcium Release Channel / drug effects*, metabolism Saline Solution, Hypertonic / pharmacology*, therapeutic use Shock, Septic / etiology, metabolism*, therapy Sodium Bicarbonate / pharmacology*, therapeutic use Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/Ryanodine Receptor Calcium Release Channel; 0/Saline Solution, Hypertonic; 144-55-8/Sodium Bicarbonate; EC 3.6.1.8/Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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