Document Detail

Effect of flow rate, negative pressure, and duration of modified ultrafiltration on hemodynamics and inflammatory mediators.
MedLine Citation:
PMID:  17237648     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate the effect of flow rate, negative pressure, and duration on modified ultrafiltration (MUF). Eighty children weighing less than 10 kg with congenital heart disease were randomly divided into four groups: group C (conventional MUF); group H (high flow rate MUF); group P (high negative pressure MUF); and group L (long duration, high flow rate MUF). The changes in body weight, hematocrit, and hemodynamics were recorded. Tumor necrosis factor and interleukin-6 were measured before bypass, bypass stop, and MUF cessation. The durations of MUF in groups H and P were significantly shorter than in the other two groups; the volume filtered in group L was much greater than in the other three groups. The changes of bodyweight, heart rate, blood pressure, and hematocrit were similar in all groups. The increased extent of inflammatory mediators was a little lower in group L. Modified ultrafiltration can reverse hemodilution and improve cardiac function even with high flow rate or negative pressure. Prolonging the duration of MUF can filter out more inflammatory mediators, but the increased trend cannot be reversed in 15 minutes.
Wei Wang; De-ming Zhu; Hui-min Huang; Xiao-man Cai; Chong Xu; Li-min Jlang; Li-song Shen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  53     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-02-01     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Department of Pediatric Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
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MeSH Terms
Blood Pressure
Cardiac Surgical Procedures / methods*
Cardiopulmonary Bypass
Heart Defects, Congenital / surgery
Heart Rate
Inflammation Mediators / blood*
Interleukin-6 / blood
Time Factors
Tumor Necrosis Factor-alpha / blood
Ultrafiltration / methods*
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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