Document Detail

Effect of flavonoid on PGE2-induced alterations in percentage collagen synthesis in ossicle organ cultures.
MedLine Citation:
PMID:  3475954     Owner:  NLM     Status:  MEDLINE    
In adult guinea-pig stapes organ cultures, 3H (2,3)-proline incorporation into the collagenase-digestible protein (CDP) and non-collagen protein (NCP) fractions of the ossicles was measured and the percentage of collagen synthesis (PCS) was calculated. Prostaglandin E2 (PGE2), a potent stimulator of bone resorption, inhibited the PCS in low concentrations (5 and 25 microM), whereas it stimulated it in pharmacological concentrations (50 and 100 microM). Ipriflavon, an isoflavone derivative of therapeutical potential in otosclerosis, also reduced the PCS in 1, 10 and 50 microM concentrations. 50 microM Ipriflavon stimulated the PCS inhibited by 5 microM PGE2, but decreased the PGE2-induced PCS enhancement in vitro.
O Ribári; I Sziklai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  103     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:    1987 May-Jun
Date Detail:
Created Date:  1987-09-11     Completed Date:  1987-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  657-60     Citation Subset:  IM    
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MeSH Terms
Collagen / biosynthesis*
Ear Ossicles / drug effects,  metabolism*
Flavonoids / pharmacology*
Guinea Pigs
Isoflavones / pharmacology*
Organ Culture Techniques
Prostaglandins E / pharmacology*
Reg. No./Substance:
0/Flavonoids; 0/Isoflavones; 0/Prostaglandins E; 35212-22-7/ipriflavone; 363-24-6/Dinoprostone; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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