| Effect of fixed-dose losartan/hydrochlorothiazide on brain natriuretic peptide in patients with hypertension. | |
| | |
MedLine Citation:
|
PMID: 21746766 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: : Losartan/hydrochlorothiazide (HCTZ) (Preminent(®)) is a fixed-dose combination of angiotensin II receptor blocker (ARB) and the thiazide diuretic HCTZ that has consistently been shown to be more effective than either losartan or HCTZ. Little is known about the relationship between losartan/HCTZ and blood levels of brain natriuretic peptide (BNP). METHODS: and results: In this study, 44 patients with hypertension who were being treated with ARB were enrolled. The ARB was changed to losartan/HCTZ because of uncontrolled hypertension. Blood pressure (BP), pulse rate (PR), plasma levels of BNP and other biochemical parameters were analyzed at baseline and 6 and 12 months after the change from ARB. Of the total 44 patients, 33 (75%) achieved the target BP at 12 months. While there was no significant change in PR, systolic and diastolic BP were significantly reduced (-23 ± 3 mmHg and -10 ± 2 mmHg, respectively) during this period. Although there were no significant changes in biochemical parameters, plasma levels of BNP were significantly decreased, especially in patients who had higher levels of BNP at baseline, during this period. CONCLUSION: : Losartan/HCTZ therapy significantly reduced not only BP but also plasma levels of BNP in patients with hypertension. These findings suggest that losartan/HCTZ might have cardioprotective effects in patients with higher levels of BNP. |
| | |
Authors:
|
Yuhei Shiga; Shin-Ichiro Miura; Ryoko Mitsutake; Yoshinari Uehara; Asao Inoue; Keijiro Saku |
Related Documents
:
|
21834976 - Hypertension and type 2 diabetes: what family physicians can do to improve control of b... 22085386 - Single-pill telmisartan and amlodipine: a rational combination for the treatment of hyp... 21789476 - Relationship of pulmonary artery wedge pressure to left atrial pressure and pulmonary v... 22158066 - Sleep-time blood pressure as a therapeutic target for cardiovascular risk reduction in ... 1521446 - Arterial ph and carbon dioxide tension as indicators of tissue perfusion during cardiac... 2979096 - Protection from coronary air embolism by a perfluorocarbon emulsion (fc-43). |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-11 |
Journal Detail:
|
Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: - ISSN: 1752-8976 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Cardiology, Fukuoka University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hype...
Next Document: Equipoise should be amended, not abandoned.