Document Detail


Effect of a fish oil-containing beverage on changes in plasma lipid fatty acids in patients with malabsorption.
MedLine Citation:
PMID:  20962312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this pilot study was to assess tolerance of a beverage containing ω-3 fatty acids (fish oil) in patients with malabsorption receiving chronic parenteral nutrition (PN). The authors wanted to determine whether fish oil could be absorbed and incorporated into plasma fatty acids and reduce markers of inflammation.
METHODS: This was a small intervention study in home-dwelling PN-dependent patients with chronic malabsorption. Ten patients were provided a drink containing 1.5 g of fish oil per day for 12 weeks. Baseline and post-supplement serum fatty acid profiles were compared.
RESULTS: Five of 10 patients withdrew from the study because of GI side effects, principally worsened diarrhea, associated with the supplement. Modest increases were found in 20:5ω-3, 22:5ω-3, and 22:6ω-3 levels in both phospholipids and triglycerides in plasma (all P < .05). In phospholipids, a reduced arachidonic acid level was seen (P = .02). These changes were not sufficient to effect improvements in serum tumor necrosis factor-alpha (TNFα), soluble TNF receptor, C-reactive protein, or interleukin-6.
CONCLUSIONS: Some patients with severe malabsorption can absorb oral ω-3 fatty acid supplements and incorporate these fatty acids into serum phospholipids and triglycerides. However, side effects are very common, and no anti-inflammatory effect was found, presumably related to the modest level of fatty acid change.
Authors:
Karen C McCowen; Pei-Ra Ling; Mario Ollero; Nicholas Tawa; Bruce R Bistrian
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition     Volume:  25     ISSN:  1941-2452     ISO Abbreviation:  Nutr Clin Pract     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2011-03-25     Revised Date:  2011-10-10    
Medline Journal Info:
Nlm Unique ID:  8606733     Medline TA:  Nutr Clin Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517-23     Citation Subset:  IM; N    
Affiliation:
Harvard Vanguard Medical Associates, Boston, MA 02215, USA. kmccowen@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arachidonic Acid / analysis
Beverages*
Dietary Supplements
Fatty Acids, Omega-3 / blood*,  pharmacology,  therapeutic use*
Female
Humans
Inflammation Mediators / blood
Malabsorption Syndromes / blood,  drug therapy*
Male
Middle Aged
Parenteral Nutrition
Phospholipids / blood*,  chemistry
Pilot Projects
Triglycerides / blood*,  chemistry
Grant Support
ID/Acronym/Agency:
P30 DK040561-15/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Inflammation Mediators; 0/Phospholipids; 0/Triglycerides; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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