| Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit. | |
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MedLine Citation:
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PMID: 2369369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of dietary supplementation with fish oil was investigated in the Watanabe heritable hyperlipidemic (WHHL) rabbit. Rabbits were fed Maxepa (1 g/kg body weight) from weaning for a 6-month period and were compared to controls. Fish oil supplements resulted in significant decreases in plasma triglyceride and cholesterol at 4 weeks after the start of the study, and these differences persisted over the 6-month period. No differences in the distribution of cholesterol or triglyceride among lipoprotein particles were found, nor were there differences in low density lipoprotein particle size. The decreases in plasma cholesterol and triglyceride were accompanied by significant increases in the percent of eicosapentaenoic and docosahexaenoic acids in both plasma and platelets. Fish oil supplementation resulted in a decrease in platelet count and response to the aggregating agents adenosine diphosphate, arachidonic acid, and collagen. Systolic blood pressure was significantly lower in the rabbits fed fish oil. At the end of the study period, aortic free and esterified cholesterol and intimal surface area covered with plaque were determined in the arch and in the descending and abdominal aorta. Significantly less cholesterol was found in the descending and abdominal aorta. These differences were mirrored by decreased activities of acid lipase and N-acetyl-beta-glucosaminidase. In contrast, no differences in the intimal surface area covered with plaque were found. In conclusion, dietary fish oil resulted in a decrease in aortic lipid deposition in the WHHL rabbit, which may have been due to decreases in plasma triglyceride and cholesterol, platelet count and aggregability, and systolic blood pressure. |
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Authors:
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A H Lichtenstein; A V Chobanian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 10 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1990 Jul-Aug |
Date Detail:
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Created Date: 1990-08-13 Completed Date: 1990-08-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 597-606 Citation Subset: IM |
Affiliation:
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Boston University School of Medicine, MA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism Arteriosclerosis / metabolism* Disease Models, Animal Eicosapentaenoic Acid / blood Fatty Acids / metabolism Fish Oils / pharmacology* Hyperlipidemias / metabolism* Lipoproteins / metabolism Platelet Count / drug effects Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL-18318/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fish Oils; 0/Lipoproteins; 1553-41-9/Eicosapentaenoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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