| Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. | |
| | |
MedLine Citation:
|
PMID: 19650705 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective-To determine whether treatment of horses with firocoxib affects recovery of ischemic-injured jejunum, while providing effective analgesia. Animals-18 horses. Procedures-Horses received saline (0.9% NaCl) solution (1 mL/50 kg, IV), flunixin meglumine (1.1 mg/kg, IV, q 12 h), or firocoxib (0.09 mg/kg, IV, q 24 h; n = 6 horses/group) before 2 hours of jejunal ischemia. Horses were monitored via pain scores and received butorphanol for analgesia. After 18 hours, ischemic-injured and control mucosa were placed in Ussing chambers for measurement of transepithelial resistance and permeability to lipopolysaccharide. Histomorphometry was used to determine denuded villus surface area. Western blots for cyclooxygenase (COX)-1 and COX-2 were performed. Plasma thromboxane B(2) and prostaglandin E(2) metabolite (PGEM) concentrations were determined. Results-Pain scores did not significantly increase after surgery in horses receiving flunixin meglumine or firocoxib. Transepithelial resistance of ischemic-injured jejunum from horses treated with flunixin meglumine was significantly lower than in saline- or firocoxib-treated horses. Lipopolysaccharide permeability across ischemic-injured mucosa was significantly increased in horses treated with flunixin meglumine. Treatment did not affect epithelial restitution. Cyclooxygenase-1 was constitutively expressed and COX-2 was upregulated after 2 hours of ischemia. Thromboxane B(2) concentration decreased with flunixin meglumine treatment but increased with firocoxib or saline treatment. Flunixin meglumine and firocoxib prevented an increase in PGEM concentration after surgery. Conclusions and Clinical Relevance-Flunixin meglumine retarded mucosal recovery in ischemic-injured jejunum, whereas firocoxib did not. Flunixin meglumine and firocoxib were effective visceral analgesics. Firocoxib may be advantageous in horses recovering from ischemic intestinal injury. (Am J Vet Res 2009;70:992-1000). |
| | |
Authors:
|
Vanessa L Cook; Colleen T Meyer; Nigel B Campbell; Anthony T Blikslager |
Related Documents
:
|
3411985 - Protection of the immature myocardium. an experimental evaluation of topical cooling, s... 17217955 - Mechanisms by which epoxyeicosatrienoic acids (eets) elicit cardioprotection in rat hea... 2767115 - Cerebral ischemia in gerbils: improvement of survival after postischemic treatment with... 21644845 - A pilot study of the impact of genotype on nifedipine pharmacokinetics when used as a t... 20183965 - Pharmacokinetics of morphine after intramuscular injection in common goldfish carassius... 2565205 - On the antipyrine test in laboratory animals. studies in the dog and monkey. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American Veterinary Medical Association Volume: 235 ISSN: 0003-1488 ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
|
Languages: eng Pagination: 310 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oleander intoxication in New World camelids: 12 cases (1995-2006).
Next Document: Non-mitogenic human acidic fibroblast growth factor reduces retinal degeneration induced by sodium i...