Document Detail


Effect of finasteride treatment on suburethral prostatic microvessel density in patients with hematuria related to benign prostate hyperplasia.
MedLine Citation:
PMID:  18362489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: In the present study we evaluated the effect of short-term finasteride treatment on microvessel density (MVD) which is an indicator of prostatic angiogenesis in patients with hematuria secondary to benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: 30 patients who were candidates for BPH surgery were prospectively included in the study. All patients had history of gross hematuria and evaluated by ultrasonography and cystoscopy. The patients were randomized two groups before surgery. The treatment group consisted of 13 patients who were given 5 mg finasteride daily for 4 weeks before surgery. The control group consisted of 17 patients who did not receive finasteride before surgery. During surgery, resected suburethral and hyperplastic prostate specimens were sent for histopathologic MVD determination separately. RESULTS: Mean MVD in the suburethral portion of prostate was significantly lower in patients treated with finasteride when compared with controls (9.08 +/- 5.6 and 13.94 +/- 5.90, respectively, p < 0.05). Mean MVD for the hyperplastic portion of prostate was similar for the finasteride and control groups (14.21 +/- 7.10 and 19.75 +/- 9.73, respectively, p > 0.05). CONCLUSION: The potential role of finasteride on hematuria related to BPH may be the suppressive effect on MVD in the suburethral tissue of prostate.
Authors:
Ali Memis; Cuneyt Ozden; Ozdem Levent Ozdal; Ozer Guzel; Ozge Han; Selda Seckin
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-03-19
Journal Detail:
Title:  Urologia internationalis     Volume:  80     ISSN:  1423-0399     ISO Abbreviation:  Urol. Int.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  177-80     Citation Subset:  IM    
Affiliation:
Department of Urology, Numune Education and Research Hospital, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Aged
Enzyme Inhibitors / therapeutic use*
Finasteride / therapeutic use*
Hematuria / drug therapy*,  etiology
Humans
Male
Microcirculation* / drug effects
Middle Aged
Neovascularization, Pathologic / drug therapy
Prospective Studies
Prostate / blood supply*,  drug effects,  pathology*
Prostatic Hyperplasia / complications,  drug therapy*,  pathology*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 98319-26-7/Finasteride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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