Document Detail


Effect of field stimulation on cellular repolarization in rabbit myocardium. Implications for reentry induction.
MedLine Citation:
PMID:  1551197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have investigated the effects of electric field stimulation on membrane repolarization in rabbit papillary muscles and assessed the consequences of these effects for the dispersion of intracellular potentials and the production of a propagation wave front or unidirectional block in relatively refractory tissue. The stimuli studied had electric field strength of 0.25-14 V/cm, duration of 2 msec, and field orientation along or across the myocardial fibers. The field strengths to excite the muscles in diastole were 0.68 or 1.23 V/cm for stimuli oriented along or across the fibers, respectively (p less than 0.01, along versus across). A 2.5-V/cm stimulus given near the end of the action potential (AP) produced either no response or, after increasing the stimulus delay only 2-3 msec, a full response with almost no AP durations that were intermediate. For stimulation along and across the fibers, respectively, given at 70% of the AP duration, a 4-V/cm stimulus produced AP prolongation (measured at 90% repolarization) of 20% and 4% (p less than 0.05), an 8-V/cm stimulus produced AP prolongation of 36% and 20% (p less than 0.05), and a 14-V/cm stimulus produced AP prolongation of 36% and 30% (p = NS). For either orientation, AP prolongation by stimuli of 8 V/cm or 14 V/cm increased gradually as the stimulus delay was increased. The different effects in relatively refractory tissue of stimuli of 2.5 V/cm compared with 8 V/cm can explain the propagation wave front and block that occur with electrically induced functional reentry in the heart.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S B Knisley; W M Smith; R E Ideker
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  70     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-24     Completed Date:  1992-04-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  707-15     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, School of Engineering, Duke University, Durham, N.C.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Electric Countershock*
Heart / physiology*
Myocardium / cytology*
Rabbits
Grant Support
ID/Acronym/Agency:
HL-28429/HL/NHLBI NIH HHS; HL-33637/HL/NHLBI NIH HHS; HL-44066/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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