Document Detail

Effect of fiberoptic bronchoscopy on respiratory performance in patients with chronic airways obstruction.
MedLine Citation:
PMID:  1179328     Owner:  NLM     Status:  MEDLINE    
Lung volumes, airway resistance, expiratory flow rates, distribution of ventilation, and arterial blood gases were measured before and after fiberoptic bronchoscopy in 13 patients with moderately severe chronic airways obstruction and in 10 healthy non-smoking controls. Arterial blood gases were also monitored serially during the procedure. Arterial oxygen tension (Pao2) fell during fiberoptic bronchoscopy in both patients and controls whereas arterial carbon dioxide tension and pH remained unchanged. Control subjects had no change in lung mechanics after fiberoptic bronchoscopy. However, the patients consistently developed increased airway obstruction after fiberoptic bronchoscopy. Within 24 hours after bronchoscopy lung function in the patients returned to baseline values, except for the residual volume which remained abnormally high. The topical application of lignocaine (Lidocaine) for local anesthesia before fiberoptic bronchoscopy produced no effect on lung mechanics in nine patients and 10 controls, but Pao2 decreased in both the patient and control groups. These results indicate that fiberoptic bronchoscopy consistently inpairs lung mechanics and gas exchange in patients with chronic airways obstruction but that the impairment is mild and reversible. Lignocaine administration as well as the intubation procedure contribute to the fall in Pao2 which occurs both in the patients and in subjects without pre-existing lung disease.
B G Salisbury; L F Metzger; M D Altose; N N Stanley; N S Cherniack
Related Documents :
8404188 - Follicular bronchitis in the pediatric population.
2785598 - Pulmonary function in patients presenting with raynaud's phenomenon without an underlyi...
8469818 - Clinical and radiologic features, lung function and therapeutic results in pulmonary hi...
3856998 - Open lung biopsy in patients with acute leukemia.
21743168 - Carotid endarterectomy: results and long-term follow-up of a single institution.
11579358 - Longer longitudinal atrial dimension in patients with idiopathic paroxysmal atrial fibr...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Thorax     Volume:  30     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-12-28     Completed Date:  1975-12-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Airway Obstruction / physiopathology*
Airway Resistance
Carbon Dioxide / blood
Chronic Disease
Fiber Optic Technology
Forced Expiratory Volume
Lidocaine / pharmacology
Lung Volume Measurements
Middle Aged
Oxygen / blood
Pulmonary Ventilation
Respiratory Function Tests*
Vital Capacity
Reg. No./Substance:
124-38-9/Carbon Dioxide; 137-58-6/Lidocaine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nocturnal and morning asthma. Relationship to plasma corticosteroids and response to cortisol infusi...
Next Document:  Intraoperative autologous blood transfusion: report of a technique.