Document Detail

Effect of a fermented formula on thymus size and stool pH in healthy term infants.
MedLine Citation:
PMID:  17515847     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of fermented formula (FF) with Bifidobacterium breve C50 and Streptococcus thermophilus 065 on thymus size and stool pH of healthy term infants, ultrasound examinations and evaluations of thymus sizes and thymus indices (TI) and measurements of stool pH were performed in the same 90 term neonates on the 3rd d of life and on the 1st, 2nd, 3rd, and 4th mo of life. Thirty newborns were exclusively breast-fed while the remaining 60 were randomly assigned to receive either a FF or a standard formula (SF). The fecal pH of the breast-fed group was lower than the SF group (p < 0.05), although it was similar to that of the FF group on the third postnatal day, persisting for the entire 4 mo of the study. The difference in TI was statistically significant over repeated measurements among the groups. The FF infants showed a TI similar to the breast-fed newborns. Probiotic fermentation products have effects comparable to those of the bacteria composing the intestinal microflora supporting the idea that intestinal bacterial balance plays an important role in improving host immune responses.
Flavia Indrio; Grazia Ladisa; Angela Mautone; Osvaldo Montagna
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  62     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-100     Citation Subset:  IM    
Department of Pediatrics, Gastroenterology Division, University of Bari, Policlinico Piazza G. Cesare, 70124 Bari, Italy.
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MeSH Terms
Bifidobacterium / metabolism
Breast Feeding
Double-Blind Method
Feces / chemistry*
Food Microbiology*
Gestational Age
Hydrogen-Ion Concentration*
Infant Formula* / administration & dosage
Infant, Newborn
Streptococcus thermophilus / metabolism
Thymus Gland / anatomy & histology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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