| Effect of fentanyl on myocardial metabolism during ischemia. | |
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MedLine Citation:
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PMID: 7059056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this survey, the effect of fentanyl, a potent morphinomimetic, on myocardial metabolism and some hemodynamic variables during ischemia is described. The data presented were derived from open-chest experiments on dogs. Ischemia was induced by partial occlusion (stenosis) of a coronary artery. Inducing the stenosis twice in the same animal after a certain interval made it possible to use the animal as its own control. Control and compound series are discussed. In the compound series, fentanyl (25 microgram/kg-1) was injected IV 5 minutes before induction of the second stenosis. Fentanyl decreased the oxygen demand of the ischemic myocardium, mainly due to a reduction in heart rate, which resulted in a decrease in the breakdown of energy-rich phosphates and in the anaerobic breakdown of glucose. The latter resulted in a less pronounced production of lactate by the ischemic myocardium and hence in a diminished acidity of this tissue. The release of potassium ions during ischemia was reduced after fentanyl. The uptake of glucose by the ischemic myocardium was not affected by fentanyl, but the uptake of free fatty acids was diminished. During ischemia, the arterial free fatty acid concentration decreased after fentanyl, indicating that the compound may suppress stress responses. Although extrapolation to clinical anesthesia should be handled with care, the described findings suggest that the use of fentanyl may benefit patients with coronary artery disease during anesthesia. |
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Authors:
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R S Reneman; G J Van der Vusse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Angiology Volume: 33 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1982 Jan |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 51-63 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Blood Gas Analysis Blood Glucose Coronary Circulation / drug effects Coronary Disease / drug therapy, metabolism*, physiopathology Dogs Fatty Acids, Nonesterified / blood Fentanyl / pharmacology*, therapeutic use Hemodynamics / drug effects Hydrogen-Ion Concentration Lactates / blood Lactic Acid Myocardium / metabolism* Oxygen / blood Phosphates / blood Potassium / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Phosphates; 437-38-7/Fentanyl; 50-21-5/Lactic Acid; 7440-09-7/Potassium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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