| Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. | |
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MedLine Citation:
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PMID: 22134388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the impact of felodipine with irbesartan on sexual function compared with felodipine with metoprolol in hypertensive women. METHODS: This was a prospective, randomized, parallel, active-controlled, open-label study (ClinicalTrials.org: NCT01238705) in 160 women (18-60 years) with mild or moderate hypertension, randomized to a once-daily treatment with felodipine combined with irbesartan or metoprolol for 48 weeks. Patients' sexual function was evaluated using a female sexual function index (FSFI) questionnaire at baseline and after 24 and 48 weeks of therapy. Levels of serum estradiol, testosterone, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) were measured. RESULTS: The two combination regimens were similarly effective in lowering blood pressure. After 48 weeks, in felodipine-irbesartan group, total scores of FSFI improved (P < 0.001). Items showing improvement in scores corresponded to desire, arousal and orgasm (P < 0.001; P = 0.002; P = 0.049, respectively). Levels of estradiol increased under treatment with felodipine-irbesartan (P = 0.003) and decreased under felodipine-metoprolol treatment (P < 0.001). The concentration of testosterone declined after felodipine-irbesartan therapy (P < 0.001) and increased under felodipine-metoprolol treatment (P < 0.001). In the felodipine-irbesartan group, decreases of 8-OHdG, 4-HNE (P < 0.001) and MDA (P < 0.001) were observed. The felodipine-irbesartan combination resulted in less oxidative stress. The differences in changes in 8-OHdG, 4-HNE and MDA between the two groups were significant (P < 0.05). CONCLUSION: These results suggested that the felodipine-irbesartan combination regimen improved sexual function in hypertensive women, whereas felodipine-metoprolol regiment did not. The reason for the different influence of these two combination therapy on female sexual function might be their different impacts on oxidative stress and hormone levels. |
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Authors:
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Ruixin Ma; Jing Yu; Dian Xu; Longquan Yang; Xin Lin; Feng Zhao; Feng Bai |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 30 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-14 Completed Date: 2012-04-03 Revised Date: 2012-06-20 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 210-6 Citation Subset: IM |
Affiliation:
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Section of Cardiology, Second Hospital of Lanzhou University, Lanzhou, Gansu Province, China. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01238705 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antihypertensive Agents / administration & dosage, adverse effects, therapeutic use* Biphenyl Compounds / administration & dosage, adverse effects, therapeutic use* Felodipine / administration & dosage, adverse effects, therapeutic use* Female Humans Hypertension / drug therapy* Metoprolol / administration & dosage, adverse effects, therapeutic use* Middle Aged Oxidative Stress / drug effects* Prospective Studies Sexuality / drug effects* Tetrazoles / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Tetrazoles; 138402-11-6/irbesartan; 37350-58-6/Metoprolol; 72509-76-3/Felodipine |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2012 Jun;30(6):1263-4; author reply 1264-5
[PMID:
22573084
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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