Document Detail


Effect of felodipine on arterial blood flow and venous function at rest in patients with mild essential hypertension.
MedLine Citation:
PMID:  9591529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Felodipine is a second-generation dihydropyridine calcium antagonist used to treat mild to moderate arterial hypertension. The authors used venous occlusion plethysmography to study the effect of this drug on lower limb arterial inflow and venous outflow in 10 at rest patients with mild essential hypertension. They also sought correlations between changes in district blood flow and blood pressure. Plethysmography was carried out at 8 AM and 4, 8, and 24 hours later at baseline (after washout), on the first day of treatment with a single daily administration of 10 mg felodipine ER, and after 7 and 30 days of treatment. The drug was given after the 8 AM evaluation. The authors determined rest flow, maximal venous incremental volume (MVIV) at 40 mmHg and 60 mmHg, and gradient of venous volume between 60 and 40 mmHg divided by the pressure difference (DV/DP) as index of venous distensibility. On the days of plethysmographic evaluation, arterial blood pressure and heart rate were measured continuously over 24 hours by the ABPM (Ambulatory Blood Pressure Monitoring). The results were analyzed by ANOVA. Rest flow, MVIV, and DV/DP were stable at the baseline evaluation. On days 1, 7, and 30 of treatment the rest flow after 4 and 8 hours was significantly greater than at 8 AM but had always returned to normal after 24 hours. No other plethysmographic parameters changed significantly; in particular venous outflow remained unchanged. Mean arterial, systolic, and diastolic blood pressure were significantly reduced, compared with baseline, following treatment on the first day and after 7 and 30 days' treatment. There was no effect on heart rate. The authors conclude that felodipine is useful for the treatment of mild essential hypertension, since it reduces arterial resistance without altering venous capacitance or distensibility.
Authors:
M Bicchi; G Vedovini; R Cappelli; S Arrigucci; G A Righi; S Forconi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  49     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-02     Completed Date:  1998-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-80     Citation Subset:  IM    
Affiliation:
Istituto di Semeiotica Medica e Geriatria, University of Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Blood Pressure / drug effects
Blood Volume / drug effects
Calcium Channel Blockers / therapeutic use*
Diastole
Felodipine / therapeutic use*
Female
Follow-Up Studies
Heart Rate / drug effects
Humans
Hypertension / drug therapy*
Leg / blood supply*
Male
Plethysmography
Regional Blood Flow / drug effects
Rest
Systole
Vascular Capacitance / drug effects
Vascular Resistance / drug effects
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Vasodilator Agents; 72509-76-3/Felodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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