Document Detail


Effect of feeding type on the efficacy of phototherapy.
MedLine Citation:
PMID:  17277429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to assess the efficacy of phototherapy for nonhemolytic hyperbilirubinemia and rebound bilirubin levels in breast-fed newborns as compared with mixed-fed (breast milk and formula) newborns.
STUDY DESIGN/SETTING: Prospective study of effects of feeding type on response to phototherapy in newborns.
METHODS: The subjects were 53 full-term healthy newborns with nonhemolytic hyperbilirubinemia [defined as total serum bilirubin 12 mg/dL (205.2 micromol/L) in the first 48 hours of life or 15 mg/dl (256.5 micromol/L), on subsequent days]. Groups were formed according to type of feeding. Group 1 consisted of 28 breast-fed newborns and group 2 consisted of 25 mixed-fed newborns. Phototherapy was terminated when total serum bilirubin concentration fell to 14 mg/dL (< 239.4 micromol/L). Rebound bilirubin measurements were obtained 24 hours after phototherapy ended.
RESULTS: The groups were comparable with respect to age at the start of phototherapy. The amount of weight loss (relative to birth weight) recorded at the start of phototherapy was significantly greater in group 1 than in group 2 (8.1+/- 3.9% vs. 5.4+/- 2.6% p = 0.004). The duration of phototherapy was significantly longer in group 1 than in group 2 (38.6+/- 12.6 h vs. 26.8+/- 9.4 h; P < 0.001). The 24-hour rate of decrease in bilirubin concentration in group 2 was significantly higher than that in group 1 [5.4+/- 2.2 mg/dL/d (92.3+/-37.6 micromol/L/d) vs. 4+/- 1.3 mg/dL/d (68.4+/- 22.2 micromol/L/d); p = 0.01]. The overall rate of decrease in bilirubin concentration in group 1 was significantly lower than that in group 2 [0.16+/- 0.05 mg/dL/h (2.73+/- 0.85 micromol/L/h) vs. 0.22+/- 0.09 mg/dL/h (3.76+/- 1.53 micromol/L/h); p = 0.01]. There was no significant difference between the two groups with respect to rebound bilirubin concentration (P = 0.184).
CONCLUSION: Phototherapy effectively reduced bilirubin levels in breastfed newborns with hyperbilirubinemia, but these patients show significantly slower response to this treatment than mixed-fed newborns.
Authors:
Hande Gulcan; Filiz Tiker; Hasan Kilicdag
Related Documents :
19953579 - High volume normal saline alone is as effective as nebulized salbutamol-normal saline, ...
16915389 - Survey of intestinal parasites in stray dogs in the madrid area and comparison of the e...
23797779 - Study of the efficacy of mizoribine in lupus nephritis in chinese patients.
11329099 - Steady-state pharmacokinetics of high-dose diltiazem hydrochloride (cardizem cd) admini...
22593439 - Broad spectrum preclinical antitumor activity of eribulin (halaven(r)): optimal effecti...
25006519 - Methotrexate induced pancytopenia.
9604449 - The effects of uvb plus calcipotriol on systemic calcium homeostasis in patients with c...
22575569 - The effect of obesity on the ed95 of propofol for loss of consciousness in children and...
9354209 - Effects of oral rabeprazole on oesophageal and gastric ph in patients with gastro-oesop...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  44     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-03-21     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
Bilirubin / blood
Breast Feeding*
Female
Humans
Hyperbilirubinemia, Neonatal / therapy*
Infant Formula*
Male
Phototherapy*
Chemical
Reg. No./Substance:
RFM9X3LJ49/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bone mineral density in beta-thalassemia major and intermedia.
Next Document:  Limiting authorship in Indian Pediatrics: an initiative to curb gift authorship.