Document Detail

Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine.
MedLine Citation:
PMID:  9263067     Owner:  NLM     Status:  MEDLINE    
Experiments were conducted to determine the effect of feeding diets containing combinations of the Fusarium metabolites deoxynivalenol (DON) and fusaric acid (FA) to starter swine. In all experiments, pigs of approximately 8.2 kg initial weight were fed diets containing blends of mycotoxin-contaminated corn, wheat, and barley for 21 d with growth and feed consumption determined weekly. In the first experiment, diets were determined to contain 0 microgram DON/g + 58.9 micrograms FA/g (control), 4.4 micrograms DON/g + 57.1 micrograms FA/g, 6.0 micrograms DON/g + 48.6 micrograms FA/g, and 7.5 micrograms DON/g + 57.4 micrograms FA/g. The feeding of all diets containing DON caused significant linear depressions in growth and feed intake after only 1 wk. Lower concentrations of DON and FA were fed in the second experiment with diets containing 0 microgram DON/g + 16.3 micrograms FA/g (control), .5 microgram DON/g + 14.3 micrograms FA/g, 1.1 micrograms DON/g + 14.1 micrograms FA/g, and 1.9 micrograms DON/g + 13.6 micrograms FA/g. There was a significant linear reduction in feed intake after 1 wk with increasing levels of dietary DON. Weight gains declined significantly only after 3 wk. Increasing amounts of FA combined with relatively constant amounts of DON were fed in the third experiment. By analysis, diets contained .5 micrograms DON/g + 2.9 micrograms FA/g (control), 2.2 micrograms DON/g + 12.2 micrograms FA/g, 2.5 micrograms DON/g + 15.6 micrograms FA/g, and 2.4 micrograms DON/g + 15.9 micrograms FA/g. In the 1st wk, the feeding of increasing amounts of fusaric acid combined with a relatively constant amount of DON caused a significant linear depression in weight gain. We concluded that a toxicological synergism exists between DON and FA when fed to immature swine and that FA concentrations in feeds should be determined whenever DON analysis is conducted.
T K Smith; E G McMillan; J B Castillo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal science     Volume:  75     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-27     Completed Date:  1997-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2184-91     Citation Subset:  IM    
Shur-Gain, Research and Nutrition, Mississauga, Ontario, Canada.
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MeSH Terms
Aging / physiology
Animal Feed / analysis,  standards*
Cereals / chemistry,  standards*
Drug Synergism
Eating / drug effects,  physiology
Fusaric Acid / analysis*,  pharmacology
Fusarium / metabolism*
Hordeum / chemistry,  standards
Mycotoxins / analysis*
Random Allocation
Swine / growth & development,  physiology*
Trichothecenes / analysis*,  pharmacology
Triticum / standards
Weight Gain / physiology
Zea mays / chemistry,  standards
Reg. No./Substance:
0/Mycotoxins; 0/Trichothecenes; 51481-10-8/deoxynivalenol; 536-69-6/Fusaric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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