Document Detail

Effect of feeding blended and interesterified vegetable oils on antioxidant enzymes in rats.
MedLine Citation:
PMID:  20937347     Owner:  NLM     Status:  In-Process    
The present study was undertaken to evaluate the effect of feeding blended and interesterified oils prepared using coconut oil (CNO) with rice bran oil (RBO) or sesame oil (SESO), with a polyunsaturated/saturated (P/S) ratio of 0.8-1.0, on oxidative stress and endogenous antioxidant system. Feeding blended oils resulted in significantly increased hepatic lipid peroxide levels in rats given blended oil CNO+RBO or CNO+SESO by 1.3 and 1.6-fold, respectively compared to rats fed diet containing CNO. The lipid peroxide level in erythrocyte membrane also increased in rats fed blended oil compared to rats fed with CNO. Rats fed interesterified oils prepared from these blended oils also showed increased lipid peroxide level compared to rats given CNO diet, however it was not significantly different from rats fed with their respective blends. There was a significant increase in the activity of endogenous antioxidant enzymes super oxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase after feeding blended and interesterified oils. The activities of Na(+)/K(+)-ATPase and Ca(2+)/Mg(2+)-ATPase were increased in rats fed blended and interesterified oils. These results indicated that the P/S ratio of dietary fat is an important factor in determining the oxidative stress, activity of endogenous antioxidant enzymes and activity of membrane bound enzymes.
Malongil B Reena; Belur R Lokesh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-15
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  49     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  136-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Lipid Science and Traditional Foods, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore, India.
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